Toll-like receptor signaling pathway (Bos taurus)

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LipoproteinInflammatory cytokinesNK cell)Antiviral effects+pInflammatory cytokines+pDegradationEndosome+pSpecific pathwayin pDCsCostimulatory moleculeseffects+peffects(anti-viral compounds)Zymosan (Yeast)+p+p+p+pUnmethylated+pPeptidoglycan(G+)+p+pLipoarabinomannan(T cell)+pCpG DNA+pAutocrine / Paracrine(Mycobacteria)dsRNAChemotacticProinflammatoryFlagellinChemotactic+peffectsLPS(G-)DNAImidazoquinolinssRNAT cell stimulation+pIKK(Neutrophil, immature DC,INFAFIKBKGTLR8CD14NFKB1TAB2INFAFINFAFMAP2K2TIRAPMAP3K7IFNAR1CD86PIK3R1PIK3R3CCL5RAC1PIK3CAMAP2K7TLR7IL6AKT1MAPK8MyD88-independent pathwaySPP1MAP3K7IP1TLR6IL12BIRAK4INFAFTLR5TRAF3IRAK1AKT2MAPK12MYD88MAPK10IRF5AKT3NFKB1RELAIL6Apoptosis pathwayTIRAPTICAM2CXCL10TNFTLR9INFAFPIK3CDINFAFMAP2K6PIK3R2INFAFTRAF6FADDIKBKEINFAFLipopolysaccharidebiosynthesisIRAK4IL6TRAF6CXCL8TLR4PIK3CBMD2IFNAR2MAP2K1PIK3R5INFAFMAP2K3TLR2IL12ATLR2FOSCASP8CCL3TLR1PIK3CGMYD88MYD88MAPK1LBPMAPK9Complement and coagulation cascadesRIPK1CD80INFAFTBK1Flagellar assemblyMAP3K8IKBKBCytokine-receptor interactionCXCL11TLR3INFAFMYD88BIKBACHUKMAPK13MAPK14MAP2K4IRF7JUNTOLLIPCD40CHUKCXCL9MAPK11TICAM1NFKB2CCL4MAPK signaling pathwayINFAFIL6IL1BMAPK3IRF3Jak-STAT signaling pathwayINFAFSTAT1Ubiquitin mediated proteolysisIRAK1MyD88-dependent pathwayTRAF6IRAK4


Description

Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. Source: KEGG:Toll-like Receptor Signaling

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(72133) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
80730view15:23, 30 June 2015Mkutmonhomology conversion
63387view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
40560view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33798view00:15, 9 December 2009MaintBotAutomatic update of empty xrefs
32525view12:57, 17 August 2009MaintBotFixed text labels
32211view12:43, 15 August 2009MaintBotFixed text labels
31699view11:49, 14 August 2009MaintBotFixed group labels
31223view19:42, 13 August 2009MaintBotFixed text labels
30636view22:28, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl)
  • Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AKT2GeneProductENSBTAG00000001400 (Ensembl)
  • Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
AKT3GeneProductENSBTAG00000017788 (Ensembl)
  • Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000
Apoptosis pathwayPathwayWP254 (WikiPathways)
BIKBAGeneProductENSBTAG00000016683 (Ensembl)
  • Original kegg element: gene;64;hsa:4792
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792
CASP8GeneProductENSBTAG00000015718 (Ensembl)
  • Original kegg element: gene;87;hsa:841
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
CCL3GeneProductOriginal kegg element: gene;44;hsa:6348
CCL4GeneProductOriginal kegg element: gene;38;hsa:6351
CCL5GeneProductENSBTAG00000007191 (Ensembl)
  • Original kegg element: gene;58;hsa:6352
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6352
CD14GeneProductENSBTAG00000015032 (Ensembl)
  • Original kegg element: gene;84;hsa:929
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:929
CD40GeneProductENSBTAG00000020736 (Ensembl)
  • Original kegg element: gene;29;hsa:958
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:958
CD80GeneProductENSBTAG00000018059 (Ensembl)
  • Original kegg element: gene;69;hsa:941
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:941
CD86GeneProductENSBTAG00000013118 (Ensembl)
  • Original kegg element: gene;28;hsa:942
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:942
CHUKGeneProductENSBTAG00000007591 (Ensembl)
  • Original kegg element: gene;42;hsa:1147
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
CXCL10GeneProductENSBTAG00000001725 (Ensembl)
  • Original kegg element: gene;25;hsa:3627
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3627
CXCL11GeneProductENSBTAG00000005603 (Ensembl)
  • Original kegg element: gene;23;hsa:6373
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6373
CXCL8GeneProductENSBTAG00000019716 (Ensembl)
  • Original kegg element: gene;43;hsa:3576
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3576
CXCL9GeneProductENSBTAG00000038639 (Ensembl)
  • Original kegg element: gene;24;hsa:4283
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4283
Complement and coagulation cascadesPathwayWP558 (WikiPathways)
Cytokine-receptor interactionPathwayWP530 (WikiPathways)
FADDGeneProductENSBTAG00000018274 (Ensembl)
  • Original kegg element: gene;56;hsa:8772
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
FOSGeneProductENSBTAG00000004322 (Ensembl)
  • Original kegg element: gene;35;hsa:2353 hsa:3725
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
Flagellar assemblyPathway
IFNAR1GeneProductENSBTAG00000021819 (Ensembl)
  • Original kegg element: gene;49;hsa:3454 hsa:3455
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3454
IFNAR2GeneProductENSBTAG00000015212 (Ensembl)
  • Original kegg element: gene;49;hsa:3454 hsa:3455
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455
IKBKBGeneProductENSBTAG00000007599 (Ensembl)
  • Original kegg element: gene;36;hsa:3551
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
IKBKEGeneProductENSBTAG00000010408 (Ensembl)
  • Original kegg element: gene;54;hsa:9641
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9641
IKBKGGeneProductENSBTAG00000006268 (Ensembl)
  • Original kegg element: gene;85;hsa:8517
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
IL12AGeneProductENSBTAG00000015150 (Ensembl)
  • Original kegg element: gene;45;hsa:3592 hsa:3593
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3592
IL12BGeneProductENSBTAG00000004741 (Ensembl)
  • Original kegg element: gene;45;hsa:3592 hsa:3593
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3593
IL1BGeneProductENSBTAG00000001321 (Ensembl)
  • Original kegg element: gene;51;hsa:3553
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL6GeneProductENSBTAG00000014921 (Ensembl)
  • Original kegg element: gene;57;hsa:3569
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
IL6GeneProductENSBTAG00000046456 (Ensembl)
  • Original kegg element: gene;1;hsa:3456
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
INFAFGeneProductENSBTAG00000046824 (Ensembl)
  • Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3452
IRAK1GeneProductENSBTAG00000016085 (Ensembl)
  • Original kegg element: gene;41;hsa:3654
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3654
IRAK4GeneProductENSBTAG00000021105 (Ensembl)
  • Original kegg element: gene;86;hsa:51135
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51135
IRF3GeneProductENSBTAG00000006633 (Ensembl)
  • Original kegg element: gene;67;hsa:3661
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3661
IRF5GeneProductENSBTAG00000004989 (Ensembl)
  • Original kegg element: gene;21;hsa:3663
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3663
IRF7GeneProductENSBTAG00000047680 (Ensembl)
  • Original kegg element: gene;20;hsa:3665
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3665
ImidazoquinolinMetabolite14697812 (Chemspider)
JUNGeneProductENSBTAG00000004037 (Ensembl)
  • Original kegg element: gene;35;hsa:2353 hsa:3725
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
Jak-STAT signaling pathwayPathwayWP619 (WikiPathways)
LBPGeneProductENSBTAG00000016864 (Ensembl)
  • Original kegg element: gene;77;hsa:3929
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3929
Lipopolysaccharide biosynthesisPathway
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • Original kegg element: gene;12;hsa:5604 hsa:5605
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • Original kegg element: gene;12;hsa:5604 hsa:5605
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3GeneProductENSBTAG00000010576 (Ensembl)
  • Original kegg element: gene;65;hsa:5606 hsa:5608
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K4GeneProductENSBTAG00000012103 (Ensembl)
  • Original kegg element: gene;63;hsa:5609 hsa:6416
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K6GeneProductENSBTAG00000001609 (Ensembl)
  • Original kegg element: gene;65;hsa:5606 hsa:5608
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAP2K7GeneProductENSBTAG00000010639 (Ensembl)
  • Original kegg element: gene;63;hsa:5609 hsa:6416
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5609
MAP3K7GeneProductENSBTAG00000002625 (Ensembl)
  • Original kegg element: gene;37;hsa:6885
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAP3K7IP1GeneProductENSBTAG00000019828 (Ensembl)
  • Original kegg element: gene;59;hsa:10454
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10454
MAP3K8GeneProductENSBTAG00000011600 (Ensembl)
  • Original kegg element: gene;13;hsa:1326
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1326
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MAPK10GeneProductENSBTAG00000020048 (Ensembl)
  • Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK11GeneProductENSBTAG00000030182 (Ensembl)
  • Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5600
MAPK12GeneProductENSBTAG00000019574 (Ensembl)
  • Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300
MAPK13GeneProductENSBTAG00000010007 (Ensembl)
  • Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5603
MAPK14GeneProductENSBTAG00000020783 (Ensembl)
  • Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • Original kegg element: gene;11;hsa:5594 hsa:5595
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl)
  • Original kegg element: gene;11;hsa:5594 hsa:5595
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK8GeneProductENSBTAG00000007876 (Ensembl)
  • Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9GeneProductENSBTAG00000004709 (Ensembl)
  • Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MD2GeneProductENSBTAG00000008864 (Ensembl)
  • Original kegg element: gene;71;hsa:23643
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23643
MYD88GeneProductENSBTAG00000000563 (Ensembl)
  • Original kegg element: gene;47;hsa:4615
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615
MyD88-dependent pathwayPathway
MyD88-independent pathwayPathway
NFKB1GeneProductENSBTAG00000020270 (Ensembl)
  • Original kegg element: gene;14;hsa:4790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2GeneProductENSBTAG00000006017 (Ensembl)
  • Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4791
PIK3CAGeneProductENSBTAG00000009232 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3CBGeneProductENSBTAG00000006909 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5291
PIK3CDGeneProductENSBTAG00000018984 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293
PIK3CGGeneProductENSBTAG00000020848 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PIK3R1GeneProductENSBTAG00000010989 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2GeneProduct
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PIK3R3GeneProductENSBTAG00000002979 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8503
PIK3R5GeneProductENSBTAG00000005978 (Ensembl)
  • Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533
RAC1GeneProductENSBTAG00000009233 (Ensembl)
  • Original kegg element: gene;48;hsa:5879
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RELAGeneProductENSBTAG00000013895 (Ensembl)
  • Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
RIPK1GeneProductENSBTAG00000006378 (Ensembl)
  • Original kegg element: gene;17;hsa:8737
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
SPP1GeneProductENSBTAG00000005260 (Ensembl)
  • Original kegg element: gene;15;hsa:6696
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696
STAT1GeneProductENSBTAG00000007867 (Ensembl)
  • Original kegg element: gene;62;hsa:6772
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
TAB2GeneProductENSBTAG00000013454 (Ensembl)
  • Original kegg element: gene;61;hsa:23118
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23118
TBK1GeneProductENSBTAG00000017401 (Ensembl)
  • Original kegg element: gene;52;hsa:29110
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29110
TICAM1GeneProductENSBTAG00000019966 (Ensembl)
  • Original kegg element: gene;82;hsa:148022
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:148022
TICAM2GeneProductENSBTAG00000002357 (Ensembl)
  • Original kegg element: gene;80;hsa:353376
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:353376
TIRAPGeneProductENSBTAG00000021504 (Ensembl)
  • Original kegg element: gene;83;hsa:114609
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114609
TLR1GeneProductOriginal kegg element: gene;75;hsa:7096
TLR2GeneProductENSBTAG00000008008 (Ensembl)
  • Original kegg element: gene;74;hsa:7097
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7097
TLR3GeneProductENSBTAG00000008682 (Ensembl)
  • Original kegg element: gene;73;hsa:7098
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7098
TLR4GeneProductENSBTAG00000006240 (Ensembl)
  • Original kegg element: gene;79;hsa:7099
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7099
TLR5GeneProductENSBTAG00000000477 (Ensembl)
  • Original kegg element: gene;72;hsa:7100
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7100
TLR6GeneProductENSBTAG00000014031 (Ensembl)
  • Original kegg element: gene;76;hsa:10333
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10333
TLR7GeneProductENSBTAG00000022161 (Ensembl)
  • Original kegg element: gene;39;hsa:51284 hsa:51311
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51284
TLR8GeneProductOriginal kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProductENSBTAG00000018198 (Ensembl)
  • Original kegg element: gene;78;hsa:54106
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54106
TNFGeneProductENSBTAG00000025471 (Ensembl)
  • Original kegg element: gene;66;hsa:7124
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
TOLLIPGeneProductENSBTAG00000008237 (Ensembl)
  • Original kegg element: gene;81;hsa:54472
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54472
TRAF3GeneProductENSBTAG00000013475 (Ensembl)
  • Original kegg element: gene;16;hsa:7187
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7187
TRAF6GeneProductENSBTAG00000036009 (Ensembl)
  • Original kegg element: gene;53;hsa:7189
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189
Ubiquitin mediated proteolysisPathway

Annotated Interactions

No annotated interactions
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