Matrix Metalloproteinases (Bos taurus)

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1MatrilysinInhibitorsMetalloelastaseCollagenasesOtherPotential Inducers of TranscriptionStromelysinsMembrane-type MMPsBased on Vu & Werb (2000)Matrix metalloproteinases: effectors of development and normal physiology.Genes Dev 14:2123-2133GelatinasesEnamelysinMMP8MMP1MMP11MMP28MMP23AMMP-16TIMP3MMP10MMP15MMP14TNFMMP13TIMP1MMP2MMP7MMP25MMP17MMP20TCF20MMP19MMP3MMP23BMMP21BSGMMP26TIMP4MMP24TIMP2MMP27MMP12MMP9


Description

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP129(72054) with a 87.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
80887view15:29, 30 June 2015Mkutmonhomology conversion
67449view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
63462view17:19, 10 May 2013MaintBotUpdated to 2013 gpml schema
40597view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35337view08:38, 12 February 2010ThomasModified description
35336view08:38, 12 February 2010Thomasmoved reference from comments to bibliography
33834view00:30, 9 December 2009MaintBotAutomatic update of empty xrefs
32519view12:55, 17 August 2009MaintBotFixed text labels
32206view12:41, 15 August 2009MaintBotFixed text labels
31693view11:47, 14 August 2009MaintBotFixed group labels
31217view19:40, 13 August 2009MaintBotFixed text labels
30629view22:25, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BSGGeneProductENSBTAG00000016648 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:682
MMP-16GeneProductENSBTAG00000006877 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4325
MMP10GeneProductENSBTAG00000037768 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4319
MMP11GeneProductENSBTAG00000006108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4320
MMP12GeneProduct
MMP13GeneProductENSBTAG00000015059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4322
MMP14GeneProductENSBTAG00000014824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4323
MMP15GeneProductENSBTAG00000012919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4324
MMP17GeneProductENSBTAG00000002145 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4326
MMP19GeneProductENSBTAG00000009051 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4327
MMP1GeneProductENSBTAG00000048029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4312
MMP20GeneProductENSBTAG00000014251 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9313
MMP21GeneProduct
MMP23AGeneProduct
MMP23BGeneProductENSBTAG00000010732 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8510
MMP24GeneProductENSBTAG00000010024 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10893
MMP25GeneProductENSBTAG00000016424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64386
MMP26GeneProduct
MMP27GeneProductENSBTAG00000040567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64066
MMP28GeneProductENSBTAG00000006086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79148
MMP2GeneProductENSBTAG00000019267 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4313
MMP3GeneProductENSBTAG00000037768 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4314
MMP7GeneProductENSBTAG00000004594 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4316
MMP8GeneProductENSBTAG00000046732 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4317
MMP9GeneProductENSBTAG00000020676 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4318
TCF20GeneProductENSBTAG00000000662 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6942
TIMP1GeneProductENSBTAG00000005043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7076
TIMP2GeneProductENSBTAG00000010899 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7077
TIMP3GeneProductENSBTAG00000020638 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7078
TIMP4GeneProductENSBTAG00000020263 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7079
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124

Annotated Interactions

No annotated interactions
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