Estrogen metabolism (Bos taurus)

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3, 6, 721211111112244288722818222114125222412DNA adductsDNA adductsDNA adductsDNA adductsEstradiolUGT1A8Estrone-17-glucuronideUGT2B72-Methoxyestrone 3-glucuronideOxygenUGT1A9OxygenSULT1E1ARSESuperoxide2-Hydroxyestrone-3-glucuronideSULT1A14-hydroxy-estradiol-4-glucuronideUGT2B7CYP1A1OxygenUGT1A8Estradiol-3,4-quinone2-HydroxyestradiolUGT1A8SuperoxideEstrone-3,4-quinoneCYP1B1COMTSuperoxide2-hydroxy-estradiol-2-glucuronideCOMTUGT1A82-hydroxyestradiol-3-glucuronide4-hydroxyestradiolEstradiol-3-glucuronideUGT1A3GSTA2Estrone sulfateEstradiol-17-glucuronideSTSARSDSULT1A1SuperoxideEstrone-3,4-semiquinone2-MethoxyestradiolNQO1UGT1A1UGT1A84-hydroxyestrone-3-glucuronideEstrone4-Hydroxyestradiol-3-glucuronideUGT1A1UGT1A8UGT1A1UGT1A8CYP3A4Estrone-3-glucuronideGSTM1SULT1A1COMT4-Methoxyestrone-3-glucuronide2-MethoxyestroneUGT1A14-MethoxyestroneNQO1UGT1A1UGT1A8Estradiol sulfateCYP1A2UGT1A8Estrone-2,3-semiquinoneEstradiol-2,3-quinoneUGT1A82-HydroxyestroneCYP3A4UGT1A14-hydroxy-estradiol-sulfateUGT1A94-hydroxyestrone2-Methoxyestradiol-3-glucuronide2-hydroxy-estradiol-sulfateEstradiol-3,4-semiquinoneUGT2B7OxygenCOMTEstrone-2,3-quinone4-Methoxyestradiol-3-glucuronideUGT2B716a-HydroxyestroneCYP1A1Estradiol-2,3-semiquinoneCYP1A24-Methoxyestradiol


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP697(80025) with a 68.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed
  2. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed
  3. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed
  4. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed
  5. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed
  6. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed
  7. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed
  8. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed

History

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CompareRevisionActionTimeUserComment
86855view07:22, 14 July 2016Mkutmonfixed ontology tags
86854view07:20, 14 July 2016MkutmonOntology Term : 'C18-steroid hormone biosynthetic pathway' added !
80678view15:21, 30 June 2015Mkutmonhomology conversion
72370view09:53, 13 November 2013EgonwFixed the PubChem-compound database name.
72161view12:17, 25 October 2013Nunoconnected lines
70169view00:31, 13 July 2013AlexanderPicoModified title
63466view17:19, 10 May 2013MaintBotUpdated to 2013 gpml schema
58828view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40602view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33839view00:31, 9 December 2009MaintBotAutomatic update of empty xrefs
31687view11:45, 14 August 2009MaintBotFixed group labels
30622view22:23, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
16a-HydroxyestroneMetaboliteHMDB00335 (HMDB)
2-HydroxyestradiolMetaboliteHMDB00338 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
2-HydroxyestroneMetaboliteHMDB00343 (HMDB)
2-Methoxyestradiol-3-glucuronideMetabolite
2-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
2-Methoxyestrone 3-glucuronideMetaboliteHMDB04482 (HMDB)
2-MethoxyestroneMetaboliteHMDB00010 (HMDB)
2-hydroxy-estradiol-2-glucuronideMetabolite
2-hydroxy-estradiol-sulfateMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
4-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
4-MethoxyestroneMetabolite
4-Methoxyestrone-3-glucuronideMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
4-hydroxy-estradiol-sulfateMetabolite
4-hydroxyestradiolMetabolite
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
ARSDGeneProduct
ARSEGeneProductENSBTAG00000014932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157399
COMTGeneProductENSBTAG00000019516 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000093010
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
EstradiolMetabolite
Estradiol sulfateMetabolite
Estradiol-17-glucuronideMetabolite
Estradiol-2,3-quinoneMetabolite
Estradiol-2,3-semiquinoneMetabolite
Estradiol-3,4-quinoneMetabolite
Estradiol-3,4-semiquinoneMetabolite
Estradiol-3-glucuronideMetaboliteHMDB06224 (HMDB)
Estrone sulfateMetaboliteHMDB01425 (HMDB)
Estrone-17-glucuronideMetaboliteHMDB04483 (HMDB)
Estrone-2,3-quinoneMetabolite148381 (PubChem-compound)
Estrone-2,3-semiquinoneMetabolite
Estrone-3,4-quinoneMetabolite114862 (PubChem-compound)
Estrone-3,4-semiquinoneMetabolite
Estrone-3-glucuronideMetaboliteHMDB04483 (HMDB)
EstroneMetaboliteHMDB00145 (HMDB)
GSTA2GeneProductENSBTAG00000006546 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243955
GSTM1GeneProduct
NQO1GeneProductENSBTAG00000020632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181019
OxygenMetaboliteHMDB01377 (HMDB)
STSGeneProductENSBTAG00000020789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:412
SULT1A1GeneProductENSBTAG00000008635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196502
SULT1E1GeneProductENSBTAG00000011952 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109193
SuperoxideMetaboliteHMDB02168 (HMDB)
UGT1A1GeneProductENSBTAG00000026181 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54658
UGT1A3GeneProductENSBTAG00000048275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54659
UGT1A8GeneProduct
UGT1A9GeneProduct
UGT2B7GeneProductENSBTAG00000040337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171234

Annotated Interactions

No annotated interactions
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