ID signaling pathway (Bos taurus)

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Regulation of gene expressionReceptorEnzyme complexLigandsLigandReceptorProteinmRNAID Signaling PathwayELK4CDK2PAX8ELK3ELK1PAX5SREBF1ID3RB1RBL1CCNE1MYOD1RBL2PAX2PID2PInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageID1ID1/ ID2/ ID3 protein expressionProtein


Description

The Inhibitor of DNA binding (ID) proteins belong to the class V HLH family of transcription factors. Four ID proteins (ID 1-4)are known in humans. Unlike the basic HLH (bHLH) transcription factors, ID proteins lack the basic DNA binding region. They can heterodimerize with class I bHLH transcription factors to form inactive complexes. They thus act as dominant negative inhibitors of the class I bHLH transcription factors. They are also capable of regulating the activity of class II HLH transcription factors. Since, class I and II HLH proteins regulate the expression of cell type-specific genes and differentiated phenotype, ID proteins are thought to regulate the cross-talk between the pathways involved in cell growth and differentiation. Aberrant expression of ID proteins are found in many primary tumors and are found to regulate many steps in cancer progression including neo-angiogenesis, invasion and migration, proliferation and growth, cell-cell interaction and differentiation. These include head and neck squamous cell carcinoma, esophageal squamous cell carcinoma, melanoma, hepatocellular carcinonoma, pancreatic cancer, ovarian cancer, cervical cancer, breast cancer and prostate cancer. Among the transcription factors that ID proteins associate with are the Ets family members (ELKs) and paired box family (PAXs). They can also bind to the retinoblastoma and retinoblastoma-like proteins (RBLs), which are thought to be tumor suppressors. IDs can also be phosphorylated by CDK2.

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP53(67360) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
80890view15:30, 30 June 2015Mkutmonhomology conversion
78781view14:13, 27 January 2015Zariminor change
67355view10:41, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
63455view17:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40589view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35751view23:59, 12 February 2010AlexanderPico
33827view00:27, 9 December 2009MaintBotAutomatic update of empty xrefs
32515view12:53, 17 August 2009MaintBotFixed text labels
31213view19:38, 13 August 2009MaintBotFixed text labels
30621view22:22, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCNE1ProteinENSBTAG00000004735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CDK2ProteinENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
ELK1ProteinENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK3ProteinENSBTAG00000001509 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2004
ELK4ProteinENSBTAG00000004953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
ID1ProteinENSBTAG00000016169 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3397
ID2ProteinENSBTAG00000021187 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3398
ID3ProteinENSBTAG00000030425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3399
MYOD1ProteinENSBTAG00000002216 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4654
PAX2ProteinENSBTAG00000021566 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5076
PAX5ProteinENSBTAG00000012498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5079
PAX8ProteinENSBTAG00000019354 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7849
RB1ProteinENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RBL1ProteinENSBTAG00000011541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933
RBL2ProteinENSBTAG00000016243 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
SREBF1ProteinENSBTAG00000007884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6720

Annotated Interactions

No annotated interactions
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