Oxidative Stress (Bos taurus)

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1Induction ofantioxidant genesStress-regulated MAP kinaseImmediate-earlygene inductionRepression of ROS-producing systemsInhibition of oxidasesReactive Oxygen SpeciesAdaptive responseTF inhibitionRepressionTF activationActivationGPX3XDHSP1SOD1NFE2L2FOSHMOX1TXNRD1NQO1CATGCLCTXN2ECSODMAOAMAPK10GSTT1JUNBMT1XMGST1NOX4TXNRD2UGT1A6SOD2GPX1NFKB1CYP1A1MAPK14GSRNFIXCYBA


Description

Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of tissues can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Some reactive oxidative species can even act as messengers through a phenomenon called redox signaling.

In humans, oxidative stress is involved in many diseases. Examples include Sickle Cell Disease,[1] atherosclerosis, Parkinson's disease, heart failure, myocardial infarction, Alzheimer's disease, Schizophrenia, Bipolar disorder, fragile X syndrome[2] and chronic fatigue syndrome, but short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.[3] Reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens.

Source: Wikipedia (wikipedia:Oxidative_stress)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP408(78546) with a 90.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Morel Y, Barouki R; ''Repression of gene expression by oxidative stress.''; Biochem J, 1999 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
80921view15:31, 30 June 2015Mkutmonhomology conversion
71403view19:00, 17 October 2013MaintBotAutomated update of data sources
63336view21:13, 9 May 2013MaintBotUpdated to 2013 gpml schema
40516view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
33759view00:02, 9 December 2009MaintBotAutomatic update of empty xrefs
32514view12:53, 17 August 2009MaintBotFixed text labels
32202view12:38, 15 August 2009MaintBotFixed text labels
31685view11:45, 14 August 2009MaintBotFixed group labels
31212view19:37, 13 August 2009MaintBotFixed text labels
30619view22:22, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CATGeneProductENSBTAG00000020980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:847
CYBAGeneProductENSBTAG00000003895 (Ensembl)
  • Probe set ID: u18729
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1535
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1543
ECSODGeneProductENSBTAG00000013980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6649
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GCLCGeneProductENSBTAG00000015571 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
GPX1GeneProduct
GPX3GeneProductENSBTAG00000043553 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2878
GSRGeneProductENSBTAG00000007115 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2936
GSTT1GeneProductENSBTAG00000040298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2953
HMOX1GeneProductENSBTAG00000015582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3162
JUNBGeneProductENSBTAG00000012046 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3726
MAOAGeneProductENSBTAG00000016206 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4128
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MGST1GeneProductENSBTAG00000008541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4257
MT1XGeneProduct
NFE2L2GeneProductENSBTAG00000019255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116044
NFIXGeneProductENSBTAG00000018229 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4784
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NOX4GeneProductENSBTAG00000018540 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50507
NQO1GeneProductENSBTAG00000020632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1728
Reactive Oxygen SpeciesMetaboliteCHEBI:26523 (ChEBI)
SOD1GeneProductENSBTAG00000018854 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6647
SOD2GeneProductENSBTAG00000006523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6648
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
TXN2GeneProductENSBTAG00000000014 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25828
TXNRD1GeneProductENSBTAG00000013912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7296
TXNRD2GeneProductENSBTAG00000043581 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10587
UGT1A6GeneProduct
XDHGeneProductENSBTAG00000012519 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7498

Annotated Interactions

No annotated interactions
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