G Protein Signaling Pathways (Bos taurus)

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1, 2TranscriptioncAMPPhosphodiesterasesAKAPsG12/13G gammaProtein Kinase CCellResponseGsG betaTranscriptionAdenylate CyclasesGqCytoskeletalChangesCellResponseProtein Kinase AGiPhosphatase 2BGNAI2PDE1AAKAP12GNAO1ADCY1PRKACGPRKCBPDE8ANRASGNB3GNA14PRKAR1APDE4BAKAP5GNG8GNGT1IP3GNG3GNASAKAP13GNAQPDE1BRHOAGNAI1ADCY8GNA11RRASADCY3AKAP11KCNJ3PRKAR2BPDE7AGNG10ADCY2HRASGNAI1PRKCHGNG12ADCY4PRKCGPRKAR2APLCB3GNG13KRASGNA15PDE7BPDE1CGNAI3PRKACAPDE8BGNB2ADCY6PRKD3ADCY5PRKCQITPR1PPP3CAGNG4GNALAKAP4PRKAR1BCALM1cAMPPRKCEARHGEF1PPP3CCGNAZAKAP1AKAP3AKAP7PRKD1ADCY9GNA13PPP3CCDAGAKAP8PRKCZGNA12AKAP6GNB5GNGT2GNG7GNG11PRKCDGNG5AKAP9AKAP10GNB1GNAO1PDE4DCa2+SLC9A1PRKCAPDE4CADCY7PRKACBPDE4APRKCIAKAP2


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(79952) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC
  2. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106003view11:53, 16 August 2019MaintBotHMDB identifier normalization
80727view15:23, 30 June 2015Mkutmonhomology conversion
71426view19:03, 17 October 2013MaintBotAutomated update of data sources
67258view10:27, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
63448view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40582view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35321view08:21, 12 February 2010ThomasModified description
35320view08:21, 12 February 2010Thomasadded literature
33819view00:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32513view12:52, 17 August 2009MaintBotFixed text labels
32201view12:38, 15 August 2009MaintBotFixed text labels
31684view11:45, 14 August 2009MaintBotFixed group labels
31211view19:37, 13 August 2009MaintBotFixed text labels
30618view22:21, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY1GeneProductENSBTAG00000009520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:107
ADCY2GeneProductENSBTAG00000019210 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
ADCY3GeneProductENSBTAG00000018705 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
ADCY4GeneProductENSBTAG00000018419 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196883
ADCY5GeneProductENSBTAG00000018777 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:111
ADCY6GeneProductENSBTAG00000005464 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112
ADCY7GeneProductENSBTAG00000006208 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:113
ADCY8GeneProductENSBTAG00000014600 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114
ADCY9GeneProductENSBTAG00000016629 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:115
AKAP10GeneProductENSBTAG00000003439 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11216
AKAP11GeneProductENSBTAG00000014752 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11215
AKAP12GeneProductENSBTAG00000014788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9590
AKAP13GeneProductENSBTAG00000037383 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11214
AKAP1GeneProductENSBTAG00000025320 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8165
AKAP2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000014471;En:ENSBTAG00000014471;
AKAP3GeneProductENSBTAG00000001020 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10566
AKAP4GeneProductENSBTAG00000016399 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8852
AKAP5GeneProductENSBTAG00000009642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9495
AKAP6GeneProductENSBTAG00000017719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9472
AKAP7GeneProductENSBTAG00000000240 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9465
AKAP8GeneProductENSBTAG00000001807 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10270
AKAP9GeneProductENSBTAG00000007442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10142
ARHGEF1GeneProductENSBTAG00000018912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9138
CALM1GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000001575;En:ENSBTAG00000025644;
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteC00165 (KEGG Compound)
GNA11GeneProductENSBTAG00000012181 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2767
GNA12GeneProductENSBTAG00000017871 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2768
GNA13GeneProductENSBTAG00000046174 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10672
GNA14GeneProductENSBTAG00000021127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9630
GNA15GeneProductENSBTAG00000019988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2769
GNAI1GeneProductENSBTAG00000002714 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770
GNAI2GeneProductENSBTAG00000020645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771
GNAI3GeneProductENSBTAG00000013016 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773
GNALGeneProductENSBTAG00000002125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2774
GNAO1GeneProductENSBTAG00000003794 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2775
GNAQGeneProductENSBTAG00000009789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNASGeneProductENSBTAG00000017475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GNAZGeneProductENSBTAG00000047664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2781
GNB1GeneProductENSBTAG00000000215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
GNB2GeneProductENSBTAG00000006495 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2783
GNB3GeneProductENSBTAG00000016043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2784
GNB5GeneProductENSBTAG00000003762 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10681
GNG10GeneProductENSBTAG00000009087 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2790
GNG11GeneProductENSBTAG00000000820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2791
GNG12GeneProductENSBTAG00000035697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55970
GNG13GeneProductENSBTAG00000033526 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51764
GNG3GeneProductENSBTAG00000002508 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2785
GNG4GeneProductENSBTAG00000002908 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2786
GNG5GeneProductENSBTAG00000008122 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2787
GNG7GeneProductENSBTAG00000007644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2788
GNG8GeneProductENSBTAG00000017762 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:94235
GNGT1GeneProductENSBTAG00000002674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792
GNGT2GeneProductENSBTAG00000047325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2793
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IP3MetaboliteHMDB0001143 (HMDB)
ITPR1GeneProductENSBTAG00000020455 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
KCNJ3GeneProductENSBTAG00000006159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3760
KRASGeneProduct
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
PDE1AGeneProductENSBTAG00000012100 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5136
PDE1BGeneProductENSBTAG00000004337 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5153
PDE1CGeneProductENSBTAG00000002739 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5137
PDE4AGeneProductENSBTAG00000012032 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5141
PDE4BGeneProductENSBTAG00000008636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5142
PDE4CGeneProductENSBTAG00000010652 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5143
PDE4DGeneProductENSBTAG00000000494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
PDE7AGeneProductENSBTAG00000011614 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5150
PDE7BGeneProductENSBTAG00000015888 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27115
PDE8AGeneProductENSBTAG00000015909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5151
PDE8BGeneProductENSBTAG00000020205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8622
PLCB3GeneProductENSBTAG00000012510 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331
PPP3CAGeneProductENSBTAG00000016005 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530
PPP3CCGeneProductENSBTAG00000020133 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5533
PRKACAGeneProductENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
PRKACBGeneProductENSBTAG00000011953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5567
PRKACGGeneProduct
PRKAR1AGeneProductENSBTAG00000008621 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5573
PRKAR1BGeneProductENSBTAG00000046142 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5575
PRKAR2AGeneProductENSBTAG00000014205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576
PRKAR2BGeneProductENSBTAG00000014958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5577
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCBGeneProductENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCDGeneProductENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PRKCEGeneProductENSBTAG00000020614 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
PRKCGGeneProductENSBTAG00000013550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
PRKCHGeneProductENSBTAG00000003276 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
PRKCIGeneProductENSBTAG00000001403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
PRKCQGeneProductENSBTAG00000010664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
PRKCZGeneProductENSBTAG00000014119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
PRKD1GeneProductENSBTAG00000012789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
PRKD3GeneProductENSBTAG00000001114 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23683
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
RRASGeneProductENSBTAG00000020983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6237
SLC9A1GeneProductENSBTAG00000008766 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6548
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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