TGF Beta Signaling Pathway (Bos taurus)

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2, 31Co-SmadsLigandsDNACofactorsAccessory receptorRepressorsR-SmadsRsmadsCo-smadsCofactorSMAD2TNFTGFBR1LTBP1SMAD1BAMBITGFBR1TGFBR3SMAD5BMP4TFE3SMAD2TGFBR2INHBAEP300ENGJAK1TGIF1SKICTNNB1SMAD1RUNX2ITGB6CREBBPSMAD7ZEB2SMAD3FKBP1ASTAT3MAPK9TGFB1LIFWNT1TGFB1EGFMAPK3SMAD4ZNF423SERPINE1SMAD9TGFBR2bta-mir-302aNFKB1SPP1FOXH1SMAD6TNFLEF1IFNGSKILBMP4NOGHRASZFYVE9STAT1RUNX3FOSTHBS1FSTJUNLEFTY1LEFTY21


Description

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.

Comments

GenMAPP remarks 
edited by: Nathan Salomonis
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP560(68944) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed Europe PMC
  2. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC
  3. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
80907view15:30, 30 June 2015Mkutmonhomology conversion
63374view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40546view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33786view00:11, 9 December 2009MaintBotAutomatic update of empty xrefs
31683view11:45, 14 August 2009MaintBotFixed group labels
30617view22:21, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BAMBIGeneProductENSBTAG00000003045 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25805
BMP4GeneProductENSBTAG00000003835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652
CREBBPGeneProductENSBTAG00000026403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
EGFGeneProduct
ENGGeneProductENSBTAG00000008997 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2022
EP300GeneProductENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
FKBP1AGeneProductENSBTAG00000032651 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2280
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXH1GeneProductENSBTAG00000004761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928
FSTGeneProductENSBTAG00000003329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10468
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IFNGGeneProductENSBTAG00000012529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
INHBAGeneProductENSBTAG00000002912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
ITGB6GeneProductENSBTAG00000009080 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
JAK1GeneProductENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LEF1GeneProductENSBTAG00000006844 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
LEFTY1GeneProductENSBTAG00000002855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10637
LEFTY2GeneProductENSBTAG00000002855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7044
LIFGeneProductENSBTAG00000007424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3976
LTBP1GeneProductENSBTAG00000019839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4052
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NOGGeneProductENSBTAG00000040282 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9241
RUNX2GeneProductENSBTAG00000004104 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:860
RUNX3GeneProductENSBTAG00000019800 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:864
SERPINE1GeneProductENSBTAG00000014465 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054
SKIGeneProductENSBTAG00000038716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6497
SKILGeneProductENSBTAG00000004154 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
SMAD1GeneProductENSBTAG00000002835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086
SMAD2GeneProductENSBTAG00000039916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087
SMAD3GeneProductENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMAD5GeneProductENSBTAG00000021772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4090
SMAD6GeneProductENSBTAG00000000625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4091
SMAD7GeneProductENSBTAG00000012441 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4092
SMAD9GeneProductENSBTAG00000007589 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4093
SPP1GeneProductENSBTAG00000005260 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696
STAT1GeneProductENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3GeneProductENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
TFE3GeneProductENSBTAG00000008523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7030
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TGFBR1GeneProductENSBTAG00000018035 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TGFBR2GeneProductENSBTAG00000019832 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048
TGFBR3GeneProductENSBTAG00000024269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049
TGIF1GeneProductENSBTAG00000007718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7050
THBS1GeneProductENSBTAG00000002006 (Ensembl)
  • there are 5 types of tsp
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
WNT1GeneProductENSBTAG00000015364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
ZEB2GeneProductENSBTAG00000012615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9839
ZFYVE9GeneProductENSBTAG00000014289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9372
ZNF423GeneProductENSBTAG00000017397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23090
bta-mir-302aGeneProductENSBTAG00000036428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207927

Annotated Interactions

No annotated interactions
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