TGF beta Signaling Pathway (Bos taurus)

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PP1APCPPP2junctionsTGF beta Signaling PathwayNF-kBGene expressionERK dependent of tightNUCofilinDissolutionCYpathwayCREBBPMAPK14NUP153MAPK1MYCRHOADCP1AAXIN1ROCK1SUMO1ZEB2TRAP1MEF2CMAPK8SMAD3PAK2PPM1ACCNB2COL1A2RNF111TRAF6SKP1TGFBR2SMURF2MAPK4PMLCUL1BTRCMAP4K1SMURF2SIK1TGFBR2SKP1FOSBZFYVE9MAP2K6EP300NEDD4LMAP2K1RBL2TGFBR3PRKAR2AWWP1RBL1NEDD9NUP153BCAR1SP1ITGA2TERTTHBS1CDKN1ALIMK2ITGB4YAP1SMAD7COPS5MEF2AFOSMAP2K2PDK1SKISMURF1MAPK1MAPK9MAPK9ZEB1TIEG1RBX1ITCHFOXP3TGFBR3SMAD7CDKN2BAKT1TGFB1TGFB1PARD6APIAS2RAF1JUNDUBE2IEID2CITED1MYCJUNMAPK4SMAD4C-METMAPK8BTRCMAP2K3STAMBPL1TIEG2SIN3ASTRAPDAB2ATF2SPTBN1TGFBR1NUP214MMP1SMAD4SMAD2CUL1NUP214COPS5MAP3K7IP1SMAD2UCHL5JUNBCDK1PIK3R1SNIP1TFDP1MAP2K4CDC42SMAD7PTK2SRCATF3APPCCND1E2F4ITGB1TGFBR1SMAD7SOS1SNW1ETS1SMAD3TNCTGFB1ZFYVE16SMURF1TGIF1SKILRHOAPIAS1PIK3R2GRB2E2F5AKT1TIEG1FOXH1INTB3RAC1MMP12FN1WWP1SMAD4TGFB1I1CAV1TP53MAP3K7HGSSMURF1RUNX2RNF111HDAC1KLF6PJA1RBX1AKT1SHC1MAPK14SMAD7PPPPPPPPPPPPPPPPPPProteinProteinmRNALigandReceptorProteinProtein - protein dissociationEnzyme ComplexSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculePCYNUCYNUCYNUCYNUCYNUCYNUCYNUCYNUCYNUCYNU


Description

The signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-β (TGF-β) have been extensively studied since its discovery nearly 30 years ago. TGF-β ligands belong to a large superfamily of cytokines that bears its name (TGF-β Superfamily) and includes bone morphogenic proteins, activins, inhibin, growth/differentiation factors, Mullerian inhibiting substance, Nodal, and several other structurally-related polypeptides. Mammals express three TGF-β isoforms (i.e., TGF-β1, TGF-β2, and TGF-β3) that are encoded by distinct genes in a tissue-specific and developmentally-regulated manner. TGF-β was identified originally via its stimulation of morphological transformation and anchorage-independent growth in fibroblasts; however, this cytokine is now recognized as being a potent tumor suppressor that prevents the dysregulated growth and survival of epithelial, endothelial, and hematopoietic cells. In addition, numerous studies have clearly established TGF-β as a multifunctional cytokine that plays essential roles in regulating virtually all aspects of mammalian development and differentiation, and in maintaining mammalian tissue homeostasis. The pleiotropic nature of TGF-β is highlighted by the fact that every cell in the metazoan body can produce and respond to this cytokine. Even more remarkably, malignant cells have evolved a variety of complex mechanisms capable of circumventing the tumor suppressing activities of TGF-β, and in doing so, typically convert the functions of TGF-β to that of a tumor promoter, particularly the induction of carcinoma epithelial-mesenchymal transition, invasion, and dissemination to distant organ sites. This peculiar conversion in TGF-β function is known as the "TGF-β Paradox", which underlies the lethality of TGF-β in metastatic cancer cells. Thus, elucidating the effectors and signaling modules activated by TGF-β may offer new insights into the development of novel neoadjuvants capable of effectively targeting the TGF-β pathway to significantly improve the clinical course of patients with cancer, fibrosis, or immunologic disorders. TGF-β is secreted from cells as a latent homodimeric polypeptide that becomes tethered to the extracellular matrix by latent-TGF-β-binding proteins. Mature TGF-β isoforms are activated and liberated from extracellular matrix depots by a variety of mechanisms, including proteolysis, reactive oxygen species, changes in pH, and physical interactions with integrins, thromobspondin-1, or SPARC. Once activated, mature TGF-β initiates transmembrane signaling by binding to two distinct transmembrane Ser/Thr protein kinases, termed TGF-β type I (TβR-I) and type II (TβR-II) receptors. In some cells and tissues, TGF-β also binds to a third cell surface receptor, TGF-β type III (TβR-III), which transfers TGF-β to TβR-II and TβR-I. Full activation of these cytokine:receptor ternary complexes transpires upon TβR-II-mediated transphosphorylation and activation of TβR-I, which then phosphorylates and activates the latent transcription factors, Smad2 and Smad3. Afterward, phosphorylated Smad2/3 interact physically with Smad4, with the resulting heterotrimers translocating into the nucleus to regulate the expression of TGF-β-responsive genes. These Smad-dependent events are subject to fine-tuning and crosstalk regulation in the cytoplasm by their interaction with a variety of adapter molecules, including SARA, Hgs, PML and Dab2, and with Smad7, whose inhibitory activity is modulated by STRAP, AMSH2, and Arkadia; and in the nucleus by their interaction with a variety of transcriptional activators and repressors that occur in a gene- and cell-specific manner. In addition to activating canonical Smad2/3-dependent signaling, accumulating evidence clearly links the development of a variety of human pathologies to aberrant coupling of TGF-β to its noncanonical effector molecules. Included in this ever expanding list of noncanonical signaling molecules stimulated by TGF-β are PI3K, AKT, mTOR, integrins and focal adhesion kinase, and members of the MAP kinase (e.g., ERK1/2, JNK, and p38 MAPK small GTP-binding proteins (e.g., Ras, Rho, and Rac1). The interactions and intersections between canonical and noncanonical TGF-β signaling systems are depicted in the pathway map.

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(79966) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
90030view19:38, 8 October 2016AlexanderPicoModified description
87359view09:35, 22 July 2016MkutmonModified description
87358view09:35, 22 July 2016MkutmonModified description
87357view09:32, 22 July 2016MaintBotadded missing graphids
84565view11:36, 3 March 2016MkutmonReverted to version '15:24, 30 June 2015' by Mkutmon
84564view11:35, 3 March 2016Mkutmonadded missing graph ids
80745view15:24, 30 June 2015Mkutmonhomology conversion
63366view22:23, 9 May 2013MaintBotUpdated to 2013 gpml schema
40538view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
33779view00:08, 9 December 2009MaintBotAutomatic update of empty xrefs
32510view12:51, 17 August 2009MaintBotFixed text labels
31208view19:36, 13 August 2009MaintBotFixed text labels
30614view22:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
APPProteinENSBTAG00000017753 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:351
ATF2ProteinENSBTAG00000002295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1386
ATF3ProteinENSBTAG00000008545 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:467
AXIN1ProteinENSBTAG00000016577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
BCAR1ProteinENSBTAG00000012002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
BTRCProteinENSBTAG00000007476 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8945
C-METProteinENSBTAG00000006161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
CAV1ProteinENSBTAG00000017869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
CCNB2ProteinENSBTAG00000005269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133
CCND1ProteinENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CDC42ProteinENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CDK1ProteinENSBTAG00000010109 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983
CDKN1AProteinENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN2BProteinENSBTAG00000016412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1030
CITED1ProteinENSBTAG00000045925 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4435
COL1A2ProteinENSBTAG00000013472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1278
COPS5ProteinENSBTAG00000002784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10987
CREBBPProteinENSBTAG00000026403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
CUL1ProteinENSBTAG00000008736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8454
DAB2ProteinENSBTAG00000016152 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1601
DCP1AProtein
E2F4ProteinENSBTAG00000012063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1874
E2F5ProteinENSBTAG00000009378 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1875
EID2Protein
EP300ProteinENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
ETS1ProteinENSBTAG00000002341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2113
FN1ProteinENSBTAG00000008300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2335
FOSBProteinENSBTAG00000008182 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2354
FOSProteinENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXH1ProteinENSBTAG00000004761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928
FOXP3ProteinENSBTAG00000013279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50943
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
HDAC1ProteinENSBTAG00000012698 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065
HGSProteinENSBTAG00000000411 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9146
INTB3ProteinENSBTAG00000009987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
ITCHProteinENSBTAG00000000308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83737
ITGA2ProteinENSBTAG00000019289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3673
ITGB1ProteinENSBTAG00000015910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
ITGB4ProteinENSBTAG00000018169 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691
JUNBProteinENSBTAG00000012046 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3726
JUNDProtein
JUNProteinENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KLF6ProteinENSBTAG00000015188 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1316
LIMK2ProteinENSBTAG00000010662 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3985
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3ProteinENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K4ProteinENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K6ProteinENSBTAG00000001609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAP3K7ProteinENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAP3K7IP1ProteinENSBTAG00000019828 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10454
MAP4K1ProteinENSBTAG00000021145 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK4ProteinENSBTAG00000009907 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
MAPK8ProteinENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9ProteinENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MEF2AProteinENSBTAG00000010649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4205
MEF2CProteinENSBTAG00000020701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
MMP12Protein
MMP1ProteinENSBTAG00000048029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4312
MYCProteinENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NEDD4LProteinENSBTAG00000005412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23327
NEDD9ProteinENSBTAG00000006287 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4739
NUP153ProteinENSBTAG00000017128 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9972
NUP214ProteinENSBTAG00000021896 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8021
PAK2ProteinENSBTAG00000047856 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
PARD6AProteinENSBTAG00000023734 (Ensembl)
  • Mediates epithelial-mesenchymal transition
  • GO:0045217
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50855
PDK1ProteinENSBTAG00000016836 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163
PIAS1ProteinENSBTAG00000005564 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8554
PIAS2ProteinENSBTAG00000007833 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9063
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PJA1Protein
PMLProteinENSBTAG00000015779 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5371
PPM1AProteinENSBTAG00000018127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5494
PRKAR2AProteinENSBTAG00000014205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576
PTK2ProteinENSBTAG00000009578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
RAC1ProteinENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RBL1ProteinENSBTAG00000011541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933
RBL2ProteinENSBTAG00000016243 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
RBX1ProteinENSBTAG00000030225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9978
RHOAProteinENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
RNF111ProteinENSBTAG00000014181 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54778
ROCK1ProteinENSBTAG00000008403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
RUNX2ProteinENSBTAG00000004104 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:860
SHC1ProteinENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SIK1ProteinENSBTAG00000011437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:150094
SIN3AProteinENSBTAG00000009985 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25942
SKIProteinENSBTAG00000038716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6497
SKILProteinENSBTAG00000004154 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
SKP1ProteinENSBTAG00000025191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6500
SMAD2ProteinENSBTAG00000039916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087
SMAD3ProteinENSBTAG00000012599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4ProteinENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMAD7ProteinENSBTAG00000012441 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4092
SMURF1ProteinENSBTAG00000007118 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57154
SMURF2ProteinENSBTAG00000019853 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64750
SNIP1ProteinENSBTAG00000016852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79753
SNW1ProteinENSBTAG00000008136 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22938
SOS1ProteinENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SP1ProteinENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
SPTBN1ProteinENSBTAG00000006995 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6711
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAMBPL1ProteinENSBTAG00000001298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57559
STRAPProteinENSBTAG00000014175 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11171
SUMO1ProteinENSBTAG00000009859 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7341
TERTProteinENSBTAG00000012567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7015
TFDP1ProteinENSBTAG00000019645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027
TGFB1ProteinENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TGFB1I1ProteinENSBTAG00000002391 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041
TGFBR1ProteinENSBTAG00000018035 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TGFBR2ProteinENSBTAG00000019832 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048
TGFBR3ProteinENSBTAG00000024269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049
TGIF1ProteinENSBTAG00000007718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7050
THBS1ProteinENSBTAG00000002006 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
TIEG1ProteinENSBTAG00000014396 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7071
TIEG2ProteinENSBTAG00000046218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8462
TNCProteinENSBTAG00000000575 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3371
TP53ProteinENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
TRAF6ProteinENSBTAG00000036009 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189
TRAP1ProteinENSBTAG00000020109 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10131
UBE2IProteinENSBTAG00000038866 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7329
UCHL5GeneProductENSBTAG00000013620 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51377
WWP1ProteinENSBTAG00000015720 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11059
YAP1ProteinENSBTAG00000039307 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10413
ZEB1ProteinENSBTAG00000020053 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6935
ZEB2ProteinENSBTAG00000012615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9839
ZFYVE16ProteinENSBTAG00000021577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9765
ZFYVE9ProteinENSBTAG00000014289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9372

Annotated Interactions

No annotated interactions
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