ErbB Signaling Pathway (Bos taurus)

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1-6, 8-1677Migration / InvasionAngiogenesisPancreaticCancerEndometrialcancerCa+2+pCell cycleprogression+pCell survival+p+p+p+pActivation by ErbB2overexpression (cancers)DNA+pDifferentiationGliomaAdhesionMigration+p+p+pDNANon-smallcell lungcancer+pReceptor ubiquitylationProteinsynthesis(EGFR)+pCellular targets+pNo signalingDG+pMetabolism+pDNA+pProliferationSurvival(HER2/Neu)Degradation+p+pColoncancerAdhesion+pCellular targetsIP3ERDNAAKT3GRB2ERBB4PIK3R5HRASGAB1ABL1CDKN1BERBB2TGFAERBB3ERBB3HBEGFPTK2MAPK1STAT5AAREGMAP2K7PAK4NRG3STAT5ACBLCELK1bta-mir-21EGFSRCERBB2ERBB4MYCCalcium signaling pathwayPLCG1PRKCABTCMYCCAMK2AERBB2BADbta-mir-21GGFBPP5MDM2EGFRApoptosis pathwayERBB2GSK3BMAPK8CCND1NRG2EGFRFOXO1CRKEIF4EBP1BCL2L11Cell cycle pathwayRPS6KB1EREGPDK1MAPK signaling pathwayKRASNRG4NCK1CDKN1AMAP2K1EGFRMTORmTor signaling pathwayJUNSOS1ERBB2ERBB3TP53ERBB4GRB2PIP2PIP3ARAFSHC2ELK117777


Description

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

  • ErbB-1, also named epidermal growth factor receptor (EGFR)
  • ErbB-2, also named HER2 in humans and neu in rodents
  • ErbB-3, also named HER3 and
  • ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP673(80202) with a 95.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE; ''ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.''; J Biol Chem, 2005 PubMed Europe PMC
  2. Oda K, Matsuoka Y, Funahashi A, Kitano H; ''A comprehensive pathway map of epidermal growth factor receptor signaling.''; Mol Syst Biol, 2005 PubMed Europe PMC
  3. Hynes NE, Lane HA; ''ERBB receptors and cancer: the complexity of targeted inhibitors.''; Nat Rev Cancer, 2005 PubMed Europe PMC
  4. Muthuswamy SK, Gilman M, Brugge JS; ''Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers.''; Mol Cell Biol, 1999 PubMed Europe PMC
  5. Schulze WX, Deng L, Mann M; ''Phosphotyrosine interactome of the ErbB-receptor kinase family.''; Mol Syst Biol, 2005 PubMed Europe PMC
  6. Scaltriti M, Baselga J; ''The epidermal growth factor receptor pathway: a model for targeted therapy.''; Clin Cancer Res, 2006 PubMed Europe PMC
  7. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT; ''Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.''; J Biol Chem, 2009 PubMed Europe PMC
  8. Liang J, Slingerland JM; ''Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.''; Cell Cycle, 2003 PubMed Europe PMC
  9. McCarty JH; ''The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events.''; Bioessays, 1998 PubMed Europe PMC
  10. Citri A, Yarden Y; ''EGF-ERBB signalling: towards the systems level.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC
  11. Marmor MD, Skaria KB, Yarden Y; ''Signal transduction and oncogenesis by ErbB/HER receptors.''; Int J Radiat Oncol Biol Phys, 2004 PubMed Europe PMC
  12. Olayioye MA, Neve RM, Lane HA, Hynes NE; ''The ErbB signaling network: receptor heterodimerization in development and cancer.''; EMBO J, 2000 PubMed Europe PMC
  13. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS; ''Epidermal growth factor receptor (EGFR) signaling in cancer.''; Gene, 2006 PubMed Europe PMC
  14. Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M; ''Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.''; J Biol Chem, 1998 PubMed Europe PMC
  15. Yarden Y, Sliwkowski MX; ''Untangling the ErbB signalling network.''; Nat Rev Mol Cell Biol, 2001 PubMed Europe PMC
  16. Holbro T, Hynes NE; ''ErbB receptors: directing key signaling networks throughout life.''; Annu Rev Pharmacol Toxicol, 2004 PubMed Europe PMC
  17. Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M; ''Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.''; N Engl J Med, 2010 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
108379view10:32, 15 December 2019Marvin M2Changed dashed lines into graphical lines
108363view14:54, 12 December 2019Marvin M2Connected lines
108257view14:28, 3 December 2019L DupuisConnected unconnected lines
108169view10:48, 29 November 2019FehrhartOntology Term : 'cancer' added !
108168view10:48, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
108167view10:48, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
106017view11:54, 16 August 2019MaintBotHMDB identifier normalization
97534view14:29, 24 May 2018Fehrhartupdated identifiers
80923view15:31, 30 June 2015Mkutmonhomology conversion
70168view00:30, 13 July 2013AlexanderPicoModified title
63390view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
40563view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33801view00:17, 9 December 2009MaintBotAutomatic update of empty xrefs
32509view12:51, 17 August 2009MaintBotFixed text labels
31207view19:35, 13 August 2009MaintBotFixed text labels
30613view22:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
AKT3GeneProductENSBTAG00000017788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000
ARAFGeneProductENSBTAG00000005039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:369
AREGGeneProductENSBTAG00000018134 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:374
Apoptosis pathwayPathwayWP1018 (WikiPathways)
BADGeneProductENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:572
BCL2L11GeneProductENSBTAG00000024105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10018
BTCGeneProductENSBTAG00000004237 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:685
CAMK2AGeneProductENSBTAG00000020087 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:815
CBLCGeneProductENSBTAG00000009494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23624
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CRKGeneProductENSBTAG00000005665 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
Calcium signaling pathwayPathwayWP1043 (WikiPathways)
Cell cycle pathwayPathwayWP1083 (WikiPathways)
EGFGeneProduct
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
EIF4EBP1GeneProductENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
ELK1GeneProductENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ERBB2GeneProductENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
ERBB3GeneProductENSBTAG00000010444 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2065
ERBB4GeneProductENSBTAG00000047490 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2066
EREGGeneProductENSBTAG00000010273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2069
FOXO1GeneProductENSBTAG00000044105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2308
GAB1GeneProductENSBTAG00000002813 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549
GGFBPP5GeneProductENSBTAG00000004150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3084
GRB2GeneProductENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
HBEGFGeneProductENSBTAG00000021766 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1839
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KRASGeneProduct
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K7GeneProductENSBTAG00000010639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5609
MAPK signaling pathwayPathwayWP998 (WikiPathways)
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MDM2GeneProductENSBTAG00000010422 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
NCK1GeneProductENSBTAG00000018427 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4690
NRG2GeneProductENSBTAG00000010689 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9542
NRG3GeneProductENSBTAG00000009587 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10718
NRG4GeneProduct
PAK4GeneProductENSBTAG00000013958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10298
PDK1GeneProductENSBTAG00000016836 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163
PIK3R5GeneProductENSBTAG00000005978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteHMDB0004249 (HMDB)
PLCG1GeneProductENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PTK2GeneProductENSBTAG00000009578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
RPS6KB1GeneProductENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
SHC2GeneProductENSBTAG00000016072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25759
SOS1GeneProductENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT5AGeneProductENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
TGFAGeneProductENSBTAG00000000783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7039
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
bta-mir-21RnaENSBTAG00000029897 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004
mTor signaling pathwayPathwayWP3256 (WikiPathways)

Annotated Interactions

No annotated interactions
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