p38 MAPK Signaling Pathway (Bos taurus)

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1-8?Growth Factors, UVTrophic Factors, etc.Cytokines Production,Apoptosis, etc.??TranslationDNA transcriptionStress: Osmotic shockg-radiation, AnisomycinFASL, InflammatoryCytokines, UV, etc.??MAP3K5ATF2MAP2K4MAP2K6PLA2G4ACREB1RASGRF1CDC42MAPKAPK2MAPK14RPS6KA5TGFB2HMGN1TRAF2MAPKAPK5TRADDMAXDDIT3SHC1HRASRAC1MAPK14ApoptosisMAPKAPK2GRB2MAP3K1MEF2DELK1RIPK1MKNK1TGFBR1MAP3K9MAP3K7STAT1HSPB1DAXXMYCTranscription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 97.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC
  2. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC
  3. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC
  4. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC
  5. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC
  6. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC
  7. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC
  8. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
95741view13:41, 19 January 2018Mkutmonupdated homology conversion
80992view14:02, 8 July 2015Mkutmonhomology conversion
67566view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
63316view21:05, 9 May 2013MaintBotUpdated to 2013 gpml schema
40497view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
38708view19:29, 23 September 2010AlexanderPico
38226view21:06, 27 August 2010Khanspers
38225view21:05, 27 August 2010KhanspersRemoved receptor graphics
35735view23:41, 12 February 2010KhanspersDescription and bibliography
33741view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
32506view12:50, 17 August 2009MaintBotFixed text labels
32196view12:36, 15 August 2009MaintBotFixed text labels
31675view11:43, 14 August 2009MaintBotFixed group labels
31204view19:34, 13 August 2009MaintBotFixed text labels
30606view22:17, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProductENSBTAG00000002295 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1386
ApoptosisPathwayWP254 (WikiPathways)
CDC42GeneProductNo homologues found for original id L:998
CREB1GeneProductENSBTAG00000005474 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1385
DAXXGeneProductENSBTAG00000016830 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1616
DDIT3GeneProductENSBTAG00000031544 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1649
ELK1GeneProductENSBTAG00000015817 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2002
GRB2GeneProductENSBTAG00000004736 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2885
HMGN1GeneProductENSBTAG00000006339 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3150
HRASGeneProductENSBTAG00000046644 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3265
HSPB1GeneProductENSBTAG00000011969 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3315
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5608
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K5GeneProductENSBTAG00000009065 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4217
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6885
MAP3K9GeneProductENSBTAG00000005700 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4293
MAPK14GeneProductENSBTAG00000020783 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1432
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9261
MAPKAPK5GeneProductENSBTAG00000009346 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8550
MAXGeneProductENSBTAG00000017994 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4149
MEF2DGeneProductENSBTAG00000046545 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4209
MKNK1GeneProductENSBTAG00000019933 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8569
MYCGeneProductENSBTAG00000008409 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609
PLA2G4AGeneProductENSBTAG00000013298 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5321
RAC1GeneProductENSBTAG00000009233 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5879
RASGRF1GeneProductENSBTAG00000019940 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5923
RIPK1GeneProductENSBTAG00000006378 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8737
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9252
SHC1GeneProductENSBTAG00000019838 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6464
STAT1GeneProductENSBTAG00000007867 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6772
TGFB2GeneProductENSBTAG00000005359 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7042
TGFBR1GeneProductENSBTAG00000018035 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7046
TRADDGeneProductENSBTAG00000012642 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8717
TRAF2GeneProductENSBTAG00000010497 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7186

Annotated Interactions

No annotated interactions
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