mRNA Processing (Bos taurus)

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15'Formation of the Spliceosomal B complexsnRNP Sm core complex5'3'YYYY(2a)5'CF IILariat Formation and 5'-Splice Site Cleavage5'Note: New participating members shown at each stepInternal methylation of mRNASerine/Argenine Rich Proteins(SR)exon 1U4:U5:U6 tri-snRNP complexCAFormation of the Spliceosomal E complexCFIU1 snRNP5'Poly(A) polymerase alphahnRNPsheterogeneous nuclear ribonucleoproteinsMethylation of mRNAPutative Alternative SplicingRegulatorsCstFSR-phosphatasesexon 1U5RNAi pathwayAdditional SR proteinsU2AF3'Formation of the Spliceosomal C complexAAdditional Factorsexon 2UGCleavage at the 3'-Splice-Site and Exon LigationU1U5AG65Misc.SR-kinasesexon 2Additional FactorsRNA helicasesplicesome associated helicasesYYYYAYYYY(2)Formation of the Spliceosomal B complexU6exon 1mRNA CappingU1 snRNPP-YYYY(2b)Poly(A)-binding protein II5'3'SR-proteinsSF3b14b5'35iPoCleavage of mRNA at the 3'-endexon 23'CstF3'Poly(A)pb IIAGexon 2exon 1AAAAAAAFormation of the Spliceosomal A complex5'SR-repressor proteinsSR-binding sitesright click on blue text for detailed informationFormation of the Spliceosomal A complex(2c)AAUAAAU5 snRNP5' G cap3'Poly(A) polsplicing factor SF3BAGSpt53'CPSFAGAsnRNP Sm core complexSR-proteinsCF IPiPrimary RNA transcriptCF IIpre-mRNAmRNA 3'-end processingU2intronSR-proteinsGUProcessing of Intron-Containing Pre-mRNA(1)snRNP Sm core complexdegradedsplicing factor SF3ARNA helicase AU2 snRNPYYYY5'mRNA cappingexon 2hnRNP regulatorsAGmRNA splice site selectionFormation of the active Spliceosomal C complexAGexon 15'3'mRNA splicing (major pathway)CPSFSR protein kinasesFormation of the Spliceosomal E complexUGU6 snRNPSR protein phosphatasesFormation of pre-mRNPsFormation of pre-mRNPsexon 1U2 snRNPCap BindingU2 snRNPsexon 2Rnmt (methyltransferase)Regulation ofAlternative Splicing3'U43'AAYYYYmRNA polyadenylationAU4 snRNP(3)3'PKinases Phosphorylating RS domains?5'Polr2aAdditional FactorsRngtt (capping enzyme)SR-binding sitesU4/U6Accessory ProteinsU2AFInternal methylation of mRNATRA2BSNRNP70SNRPNATPSUGP2DDX20SF3A2SNRPD1RBM39PRPF4SF3A1LSM2PRMT2SNRPGRNGTTSRSF6PRPF40AHRMT1L2PRPF8PRPF3SF3B2SF3B3SFRS5SNRPESFRS9HNRNPA1SRSF4RBM5RNMTSF3B1SRPK1SF3A3FUSIP1SRSF2NONOPOLR2ASF3B4HNRNPH1TXNL4AU1 snRNAHNRNPLDDX1U2AF1EFTUD2CSTF2TSRSF3Rnu6HNRNPRU2AF2CLP1CD2BP2SNRPB2SFSWAPSNRPD3CELF4METTL3SNRPA1SFRS12HNRPDGMPPTBP2FUSSRRM1SFPQCLK1LSM2SRP54PSKH1DHX16SNRPD2CDC40RBMXCSTF1SUGP1RBM17U5 snRNAPTBP1HNRPA3P1PRPF18CLASRPCPSF3CDC40PPM1GSRSF1DICER1SNU13NUDT21PCBP2XRN2SNRPNU4 snRNALSM7HNRNPA2B1CLK3SNRPAHNRNPUHNRPMCPSF2SRSF7YBX1SPOPHNRPH2SNU13CSTF2CLK2DHX8HNRPKFUSIP1PAPOLADHX9NCBP2CPSF4SNRPFRNPS1TMED10SNRPBDNAJC8SUPT5HHNRNPABDHX38SMC1ASNRNP40PRPF6CLK4NXF1PABPN1PRPF8CELF2PRPF4PHF5ANCBP1DHX15CELF1PRPF4BCSTF3CPSF1HNRPCSRPK2SF3B5SNU13U2


Description

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA).

The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated.

5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds.

3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion.

Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Pathway adapted from http://www.reactome.org.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP411 (r95128) with a 89.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Carmody SR, Wente SR; ''mRNA nuclear export at a glance.''; J Cell Sci, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95764view14:18, 19 January 2018MkutmonHomology conversion update
80888view15:29, 30 June 2015Mkutmonhomology conversion
71421view19:02, 17 October 2013MaintBotAutomated update of data sources
67492view11:08, 26 June 2013DdiglesOntology Term : 'spliceosome pathway' added !
63389view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
48124view05:41, 9 May 2012KhanspersUpdating from human to fix xref duplication
40562view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35238view19:44, 11 February 2010Khanspersupdated xrefs
35235view19:37, 11 February 2010KhanspersModified description
33800view00:16, 9 December 2009MaintBotAutomatic update of empty xrefs
32497view12:47, 17 August 2009MaintBotFixed text labels
32189view12:34, 15 August 2009MaintBotFixed text labels
31663view11:39, 14 August 2009MaintBotFixed group labels
31195view19:31, 13 August 2009MaintBotFixed text labels
30592view22:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
CD2BP2GeneProductENSBTAG00000015486 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10421
CDC40GeneProductENSBTAG00000000409 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51362
CELF1GeneProductENSBTAG00000002520 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10658
CELF2GeneProductENSBTAG00000008937 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10659
CELF4GeneProductENSBTAG00000004940 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:56853
CLASRPGeneProductENSBTAG00000013697 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11129
CLK1GeneProductENSBTAG00000005408 (Ensembl)
  • PMID: 15010457: Inhibitor John C. Bell, PhD

    Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: John.Bell@orcc.on.ca The control of pre-mRNA splicing by the Clk kinase family

    We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1195
CLK2GeneProductENSBTAG00000014393 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1196
CLK3GeneProductENSBTAG00000007304 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1198
CLK4GeneProductENSBTAG00000019414 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57396
CLP1GeneProductENSBTAG00000006493 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10978
CPSF1GeneProductENSBTAG00000008355 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:29894
CPSF2GeneProductENSBTAG00000010227 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:53981
CPSF3GeneProductENSBTAG00000019735 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51692
CPSF4GeneProductENSBTAG00000002090 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10898
CSTF1GeneProductENSBTAG00000006639 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1477
CSTF2GeneProductENSBTAG00000003547 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1478
CSTF2TGeneProductENSBTAG00000018406 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23283
CSTF3GeneProductENSBTAG00000008617 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1479
DDX1GeneProductENSBTAG00000009906 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1653
DDX20GeneProductENSBTAG00000018717 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11218
DHX15GeneProductENSBTAG00000008896 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1665
DHX16GeneProductENSBTAG00000006960 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8449
DHX38GeneProductNo homologues found for original id L:9785
DHX8GeneProductENSBTAG00000008339 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1659
DHX9GeneProductENSBTAG00000019821 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1660
DICER1GeneProductENSBTAG00000012852 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23405
DNAJC8GeneProductNo homologues found for original id L:22826
EFTUD2GeneProductENSBTAG00000013526 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9343
FUSGeneProductENSBTAG00000005757 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2521
FUSIP1GeneProductNo homologues found for original id L:10772
GMPMetabolite85-32-5 (CAS)
HNRNPA1GeneProductENSBTAG00000001553 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3178
HNRNPA2B1GeneProductENSBTAG00000005726 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3181
HNRNPABGeneProductENSBTAG00000013627 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3182
HNRNPH1GeneProductENSBTAG00000009389 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3187
HNRNPLGeneProductENSBTAG00000001055 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3191
HNRNPRGeneProductENSBTAG00000016578 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10236
HNRNPUGeneProductENSBTAG00000007606 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3192
HNRPA3P1GeneProduct
HNRPCGeneProductENSBTAG00000011396 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3183
HNRPDGeneProductENSBTAG00000013952 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3184
HNRPH2GeneProductENSBTAG00000007499 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3188
HNRPKGeneProductNo homologues found for original id L:3190
HNRPMGeneProductENSBTAG00000039263 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4670
HRMT1L2GeneProductENSBTAG00000006646 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3276
LSM2GeneProductENSBTAG00000005634 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57819
LSM7GeneProductENSBTAG00000004521 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51690
METTL3GeneProductENSBTAG00000015148 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:56339
NCBP1GeneProductENSBTAG00000009732 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4686
NCBP2GeneProductENSBTAG00000008873 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22916
NONOGeneProductENSBTAG00000012152 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4841
NUDT21GeneProductENSBTAG00000010207 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11051
NXF1GeneProductENSBTAG00000009488 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10482
PABPN1GeneProductENSBTAG00000006884 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8106
PAPOLAGeneProductENSBTAG00000004054 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10914
PCBP2GeneProductNo homologues found for original id L:5094
PHF5AGeneProductENSBTAG00000006423 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84844
POLR2AGeneProductNo homologues found for original id L:5430
PPM1GGeneProductENSBTAG00000019522 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5496
PRMT2GeneProductENSBTAG00000005503 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3275
PRPF18GeneProductENSBTAG00000017244 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8559
PRPF3GeneProductENSBTAG00000013946 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9129
PRPF40AGeneProductENSBTAG00000048151 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55660
PRPF4BGeneProductENSBTAG00000002086 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8899
PRPF4GeneProductENSBTAG00000004571 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9128
PRPF6GeneProductENSBTAG00000011656 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:24148
PRPF8GeneProductENSBTAG00000011488 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10594
PSKH1GeneProductENSBTAG00000018037 (Ensembl)
  • PMID: 12466556
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5681
PTBP1GeneProductENSBTAG00000045828 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5725
PTBP2GeneProductENSBTAG00000008809 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:58155
RBM17GeneProductENSBTAG00000021951 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84991
RBM39GeneProductENSBTAG00000003949 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9584
RBM5GeneProductENSBTAG00000006330 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10181
RBMXGeneProductNo homologues found for original id L:27316
RNGTTGeneProductENSBTAG00000002725 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8732
RNMTGeneProductENSBTAG00000009142 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8731
RNPS1GeneProductENSBTAG00000046336 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10921
Rnu6RnaGenBank sequence: M10329
SF3A1GeneProductENSBTAG00000003390 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10291
SF3A2GeneProductENSBTAG00000025452 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8175
SF3A3GeneProductENSBTAG00000007299 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10946
SF3B1GeneProductENSBTAG00000008915 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23451
SF3B2GeneProductENSBTAG00000002778 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10992
SF3B3GeneProductENSBTAG00000010627 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23450
SF3B4GeneProductENSBTAG00000026365 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10262
SF3B5GeneProductENSBTAG00000009795 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:83443
SFPQGeneProductENSBTAG00000016328 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6421
SFRS12GeneProductENSBTAG00000007321 (Ensembl)
  • PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:140890
SFRS5GeneProductENSBTAG00000011596 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6430
SFRS9GeneProductENSBTAG00000012792 (Ensembl)
  • PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8683
SFSWAPGeneProductENSBTAG00000000439 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6433
SMC1AGeneProductENSBTAG00000017761 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8243
SNRNP40GeneProductENSBTAG00000016817 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9410
SNRNP70GeneProductENSBTAG00000001996 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6625
SNRPA1GeneProductENSBTAG00000013593 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6627
SNRPAGeneProductENSBTAG00000009077 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6626
SNRPB2GeneProductENSBTAG00000027506 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6629
SNRPBGeneProductENSBTAG00000001038 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6628
SNRPD1GeneProductENSBTAG00000012376 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6632
SNRPD2GeneProductENSBTAG00000012177 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6633
SNRPD3GeneProductENSBTAG00000021262 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6634
SNRPEGeneProductENSBTAG00000039066 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6635
SNRPFGeneProductENSBTAG00000016271 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6636
SNRPGGeneProductNo homologues found for original id L:6637
SNRPNGeneProductENSBTAG00000008251 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6638
SNU13GeneProductENSBTAG00000006104 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4809
SPOPGeneProductENSBTAG00000005824 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8405
SRP54GeneProductENSBTAG00000019085 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6729
SRPK1GeneProductENSBTAG00000016838 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6732
SRPK2GeneProductENSBTAG00000002175 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6733
SRRM1GeneProductENSBTAG00000013772 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10250
SRSF1GeneProductENSBTAG00000014766 (Ensembl)
  • Antagonist splicing factor
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6426
SRSF2GeneProductENSBTAG00000018258 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6427
SRSF3GeneProductENSBTAG00000040006 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6428
SRSF4GeneProductENSBTAG00000013309 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6429
SRSF6GeneProductENSBTAG00000008527 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6431
SRSF7GeneProductENSBTAG00000014891 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6432
SUGP1GeneProductENSBTAG00000006116 (Ensembl)
  • inferred from: SURP 2, G patch protein, UniProt:O60378
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57794
SUGP2GeneProductENSBTAG00000013288 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10147
SUPT5HGeneProductENSBTAG00000010467 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6829
TMED10GeneProductENSBTAG00000005694 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10972
TRA2BGeneProductENSBTAG00000001697 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6434
TXNL4AGeneProductENSBTAG00000013587 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10907
U1 snRNARnaGenBank sequence: J00645
U2AF1GeneProductENSBTAG00000011645 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7307
U2AF2GeneProductENSBTAG00000002830 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11338
U2GeneProductENSBTAG00000046891 (Ensembl)
  • GenBank sequence: K00027
  • Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6066
U4 snRNARnaGenBank sequence: M10328, M18004
U5 snRNARnaGenBank sequence: AB021173
XRN2GeneProductENSBTAG00000011304 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22803
YBX1GeneProductENSBTAG00000017368 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4904

Annotated Interactions

No annotated interactions
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