FAS pathway and Stress induction of HSP regulation (Bos taurus)

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21NFK-B PathwayStressExtracellularActivateSelf-activationCytoplasmCell SurvivalApoptosomeDNA presentation3x-PFAS PathwayCut3x-PActinNucleusInhibitionStress Induction of HSP regulationMitochondria PathwayROSProteasome3x-PNecrosisHSPB1APAF1ApoptosisCYCSNFX1HSPB1CASP3MAP2K4LMNB2CASP8CASP10PhosphateBCL2PhosphateFAF1TNFDAXXCASP9SPTAN1HSPB1DFFBPhosphateCASP7CeramideHSPB1FADDGlutathionePhosphateCASP3DFFBDFFAMAPK8LMNAPhosphateFASCASP8RB1FLIPCASP6DAXXPAK1HSPB1PARP1PhosphateRIPK2FASLGPhosphateFAF1ARHGDIBIL1AACTA1HSPB1LMNB1PRKDCbta-mir-34cAPAF1HSPB1MAPKAPK2HSPB1PhosphatePAK2MAPKAPK3MAP3K1MAP3K7JUNACTBACTG1


Description

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP314(80438) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, Xu L; ''Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres.''; BMC Cancer, 2008 PubMed Europe PMC Scholia
  2. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
105979view11:50, 16 August 2019MaintBotHMDB identifier normalization
84563view11:32, 3 March 2016Mkutmonadded missing graph ids
80796view15:26, 30 June 2015Mkutmonhomology conversion
67219view10:22, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
63447view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
48131view05:50, 9 May 2012MaintBotUpdating from human to fix xref duplication
40581view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
38224view21:04, 27 August 2010KhanspersRemoved protein complex and receptor graphics
35556view14:59, 12 February 2010ThomasModified description
35553view14:58, 12 February 2010Thomasadded literature
33818view00:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32495view12:47, 17 August 2009MaintBotFixed text labels
32188view12:34, 15 August 2009MaintBotFixed text labels
31660view11:39, 14 August 2009MaintBotFixed group labels
31193view19:31, 13 August 2009MaintBotFixed text labels
30588view22:11, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA1GeneProductENSBTAG00000046332 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58
ACTBGeneProductENSBTAG00000026199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTG1GeneProductENSBTAG00000006189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
APAF1GeneProductENSBTAG00000021661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317
ARHGDIBGeneProductENSBTAG00000006039 (Ensembl)
  • Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:397
ApoptosisPathwayWP254 (WikiPathways)
BCL2GeneProductENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
CASP10GeneProduct
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
CASP6GeneProductENSBTAG00000012537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839
CASP7GeneProductENSBTAG00000006615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842
CYCSGeneProductENSBTAG00000022613 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205
CeramideMetabolite104404-17-3 (CAS)
DAXXGeneProductENSBTAG00000016830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1616
DFFAGeneProductENSBTAG00000013535 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1676
DFFBGeneProductENSBTAG00000020015 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1677
FADDGeneProductENSBTAG00000018274 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
FAF1GeneProductENSBTAG00000014482 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11124
FASGeneProductENSBTAG00000010785 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355
FASLGGeneProductENSBTAG00000032808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:356
FLIPGeneProductENSBTAG00000010998 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8837
GlutathioneMetaboliteHMDB0000125 (HMDB)
HSPB1GeneProductENSBTAG00000011969 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3315
IL1AGeneProductENSBTAG00000010349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LMNAGeneProductENSBTAG00000017574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4000
LMNB1GeneProductENSBTAG00000002882 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4001
LMNB2GeneProductENSBTAG00000013624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84823
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
MAPKAPK3GeneProductENSBTAG00000016532 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7867
NFX1GeneProductENSBTAG00000012385 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4799
PAK1GeneProductENSBTAG00000010191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
PAK2GeneProductENSBTAG00000047856 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
PARP1GeneProductENSBTAG00000000837 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:142
PRKDCGeneProductENSBTAG00000017019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
PhosphateMetaboliteHMDB0001429 (HMDB)
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RIPK2GeneProductENSBTAG00000015271 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8767
SPTAN1GeneProductENSBTAG00000015327 (Ensembl)
  • Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6709
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
bta-mir-34cRnaENSBTAG00000029991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562

Annotated Interactions

No annotated interactions
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