Type II interferon signaling (IFNG) (Bos taurus)

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1TPPTT[P]NucleusPlasmaMembraneOB&BORExtracellularSpacePOR-PBOR[P] [P]P[P]OR&[P]OAPCytoplasmBBORISG15INOSTAP1CIITA(ISGF3)STAT1STAT2STAT2IRF9IFI6IFNGR1PTPN11IRF8IFNGR2JAK1IRF9IFIT2PTPJAK2IL1BSTAT2STAT1JAK2STAT1STAT1JAK2STAT1IRF8IFNGHIST2H4IL6STAT2PSMB9STAT1STAT1STAT1IFNGPRKCDJAK1STAT1CYBBJAK2IRF1GBP1JAK1HLA-BINFAFJAK1IFNGR2EIF2AK2STAT1IFNGR1IRF9IFNGSTAT1(ISGF3)OAS1YSTAT1IRF4STAT1IFNGR1CXCL10STAT1IFNGIRF9ICAM1IFNGSTAT1CXCL9STAT1IFNGR2SOCS3SPI1IRF2IFNGR2IRF9STAT1IFNGR1SOCS1


Description

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP619(71168) with a 88.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
86918view08:07, 14 July 2016MkutmonOntology Term : 'Jak-Stat signaling pathway' added !
86917view08:06, 14 July 2016MkutmonOntology Term : 'type II interferon signaling pathway' added !
86916view08:06, 14 July 2016Mkutmonfix ontology tag issue
80691view15:22, 30 June 2015Mkutmonhomology conversion
63372view23:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
40544view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33785view00:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32494view12:47, 17 August 2009MaintBotFixed text labels
32187view12:33, 15 August 2009MaintBotFixed text labels
31658view11:38, 14 August 2009MaintBotFixed group labels
31192view19:30, 13 August 2009MaintBotFixed text labels
30586view22:11, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(ISGF3)GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000005816;En:ENSBTAG00000005815;
CIITAGeneProductENSBTAG00000020649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4261
CXCL10GeneProductENSBTAG00000001725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3627
CXCL9GeneProductENSBTAG00000038639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4283
CYBBGeneProductENSBTAG00000019953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1536
EIF2AK2GeneProductENSBTAG00000008703 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5610
GBP1GeneProductENSBTAG00000001143 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2633
HIST2H4GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000032259;En:ENSBTAG00000031762;
HLA-BGeneProductENSBTAG00000038619 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3106
ICAM1GeneProductENSBTAG00000010303 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3383
IFI6GeneProductENSBTAG00000007554 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2537
IFIT2GeneProductENSBTAG00000034918 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3433
IFNGGeneProductENSBTAG00000012529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IFNGR1GeneProductENSBTAG00000012544 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3459
IFNGR2GeneProductENSBTAG00000012899 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3460
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL6GeneProductENSBTAG00000046456 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
INFAFGeneProductENSBTAG00000046824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3440
INOSGeneProductENSBTAG00000006894 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4843
IRF1GeneProductENSBTAG00000031231 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3659
IRF2GeneProductENSBTAG00000010002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3660
IRF4GeneProductENSBTAG00000002929 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3662
IRF8GeneProductENSBTAG00000017824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3394
IRF9GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000005816;En:ENSBTAG00000005815;
ISG15GeneProductENSBTAG00000014707 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9636
JAK1GeneProductENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2GeneProductENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
OAS1YGeneProductENSBTAG00000039861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4938
PRKCDGeneProductENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PSMB9GeneProductENSBTAG00000008954 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5698
PTPGeneProduct
PTPN11GeneProductENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
SOCS1GeneProductENSBTAG00000004386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
SOCS3GeneProductENSBTAG00000008441 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021
SPI1GeneProductENSBTAG00000021709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6688
STAT1GeneProductENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT2GeneProductENSBTAG00000004380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773
TAP1GeneProductENSBTAG00000008953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6890

Annotated Interactions

No annotated interactions
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