Wnt Signaling Pathway (Bos taurus)

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1DKK1Frizzled LigandsUbiquitin Conjugating Enzyme-CateninPhosphorylatedCytoskeletonRecruitment to UnknownUbiquitin TaggedB - CateninTranscriptional ActivationBNucleusPWNT5BSFRP426S Proteasome DegradationAPCPRKCAKREMEN1FZD2CSNK1EWNT2BWNT4CTNNB1PRKCDROR1FBXW2FZD1PRKCHMAPK9CCND1PRKCQPPP2R5EFZD3WNT3AFOSL1DVL1LDLRLRP5PRKD1FZD9RAC1RYKWNT6JUNPRKCBMAPK10WNT10AAXIN1FZD5WNT16FZD7WNT7APRKCIPPP2R5CPAFAH1B1WNT5ALRP6WNT2GSK3BCCND2FZD10RHOAPLAUPRKCEFZD8MYCWNT11DVL3CCND3WNT7BPRKCZWNT10BFZD6WNT3WNT16TCF-1/LEFDVL2FRAT1ApoptosisWNT1PRKCGROR2


Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP428(79854) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
80843view15:28, 30 June 2015Mkutmonhomology conversion
71410view19:01, 17 October 2013MaintBotAutomated update of data sources
67747view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
63351view22:22, 9 May 2013MaintBotUpdated to 2013 gpml schema
40525view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35128view13:39, 11 February 2010Thomasconnected line
35120view13:24, 11 February 2010Thomasadded literature
35110view13:17, 11 February 2010ThomasModified description
33767view00:05, 9 December 2009MaintBotAutomatic update of empty xrefs
32493view12:46, 17 August 2009MaintBotFixed text labels
32186view12:33, 15 August 2009MaintBotFixed text labels
31657view11:38, 14 August 2009MaintBotFixed group labels
31191view19:30, 13 August 2009MaintBotFixed text labels
30585view22:10, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
AXIN1GeneProductENSBTAG00000016577 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
ApoptosisPathwayWP254 (WikiPathways)
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND2GeneProductENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CSNK1EGeneProductENSBTAG00000047582 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1454
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
DVL1GeneProductENSBTAG00000010696 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
DVL2GeneProductENSBTAG00000003075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
DVL3GeneProductENSBTAG00000019336 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
FBXW2GeneProductENSBTAG00000000712 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26190
FOSL1GeneProductENSBTAG00000006194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061
FRAT1GeneProductENSBTAG00000007956 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10023
FZD10GeneProductENSBTAG00000007047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11211
FZD1GeneProductENSBTAG00000002107 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8321
FZD2GeneProductENSBTAG00000020590 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2535
FZD3GeneProductENSBTAG00000006621 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7976
FZD5GeneProductENSBTAG00000020957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7855
FZD6GeneProductENSBTAG00000010529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8323
FZD7GeneProductENSBTAG00000002283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8324
FZD8GeneProductENSBTAG00000015072 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8325
FZD9GeneProductENSBTAG00000020742 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8326
GSK3BGeneProductENSBTAG00000048057 (Ensembl)
  • MOUSE:KG38 MOUSE
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KREMEN1GeneProductENSBTAG00000009773 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83999
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
LRP5GeneProductENSBTAG00000005903 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4041
LRP6GeneProductENSBTAG00000011761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4040
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
PAFAH1B1GeneProductENSBTAG00000016806 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5048
PLAUGeneProductENSBTAG00000005947 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
PPP2R5CGeneProductENSBTAG00000020192 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5527
PPP2R5EGeneProductENSBTAG00000019784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5529
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCBGeneProductENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCDGeneProductENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PRKCEGeneProductENSBTAG00000020614 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
PRKCGGeneProductENSBTAG00000013550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
PRKCHGeneProductENSBTAG00000003276 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
PRKCIGeneProductENSBTAG00000001403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
PRKCQGeneProductENSBTAG00000010664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
PRKCZGeneProductENSBTAG00000014119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
PRKD1GeneProductENSBTAG00000012789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
ROR1GeneProductENSBTAG00000012312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4919
ROR2GeneProductENSBTAG00000005092 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4920
RYKGeneProductENSBTAG00000016999 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6259
SFRP4GeneProductENSBTAG00000015366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6424
TCF-1/LEFGeneProduct
WNT10AGeneProductENSBTAG00000009217 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80326
WNT10BGeneProductENSBTAG00000015347 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7480
WNT11GeneProductENSBTAG00000010820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7481
WNT16GeneProductENSBTAG00000002940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51384
WNT1GeneProductENSBTAG00000015364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
WNT2BGeneProductENSBTAG00000014291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
WNT2GeneProductENSBTAG00000008097 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
WNT3AGeneProductENSBTAG00000039397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
WNT3GeneProductENSBTAG00000016012 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7473
WNT4GeneProductENSBTAG00000022671 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54361
WNT5AGeneProductENSBTAG00000020221 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
WNT5BGeneProductENSBTAG00000001341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81029
WNT6GeneProductENSBTAG00000013990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7475
WNT7AGeneProductENSBTAG00000001668 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7476
WNT7BGeneProductENSBTAG00000009532 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477

Annotated Interactions

No annotated interactions
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