Kit receptor signaling pathway (Bos taurus)

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RPS6KA1RPS6KA3PAKT1PKit Receptor Signaling PathwayPhospholipase DCYNUDOK1PCRKPEP300KITLGKITVAV1PFOSGAB2TECPBCL2MAP2K2PGRB7SHC1PSH2B2KITFYNUbSNAI2CRKLJAK2PTBX2PIK3R2STAT5BSOCS1PLCG1PSNAI1BTKPGRB10LYNMATKPTPN6KITCBLPSOCS6RPS6KITLGMAPTPSOS1RAF1PMAP2K1PINPP5DSTAT3STAT3PSTAT1MAPK1PFOXO3STAT1PGRB2MAPK3PPTPN11PRPS6KB1PSTAT5ASTAT5BSTAT5APJUNBPRKCABADPRKCBMAPK8MAPK8PMAPK14PIK3R1PSRCPPMITFSTAT5AHRASGTPRPS6KA1RPS6KA3RPS6KB1MAPK1MAPK3CYNUCYNUCYNUCYNUProteinInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavagemRNAReceptorLigandProteinEnzyme complex


Description

Kit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 receptor and fms-like tyrosine kinase. Kit signaling is plays important role in a number of physiological processes including erythropoiesis, lymphopoiesis, mast cell development and function, megakaryopoiesis, gametogenesis and melanogenesis. Sequence alterations in the c-kit gene are found to be associated with different cancers including hematopoietic malignancies, gastrointestinal stromal tumors, germ cell tumors, small-cell lung cancer and pancreatic cancer. The primary ligand for kit receptor is stem cell factor (SCF). It is also known as Kit ligand, steel factor or mast cell growth factor. SCF is a glycosylated, non-covalent homodimer. Alternative splicing and proteolytic cleavage results in soluble and membrane bound forms of the protein. that binds to two KIT monomers. Binding of SCF to KIT results in the dimerization of the receptor and its autophsphorylation. The residues that are known to get phosphorylated upon ligand binding include Tyr568, Tyr570, Tyr703, Tyr721, Tyr730, Tyr823, Tyr 900 and Tyr936. Signaling events downstream of the KIT receptor are well studied. Among the signaling cascades that are activated are the Ras/Raf/MEK/MAPK and the PI3K/AKT/RPS6K pathways. KIT stimulation is also known to activate the JAK/STAT and PLC/PKC signaling pathways. Among the other key proteins that are regulated by KIT are the kinases BTK, TEC, LYN, SRC, FYN and JNK. Regulation of KIT receptor tyrosine kinase occurs through many mechanisms. Activated KIT receptors are degraded via CBL, a E3 ubiquitin-protein ligase. CBL induces the degradation of the receptor via the proteasome or lysosome. KIT can also be dephosphorylated and inactivated by the protein tyrosine phosphatase Shp1. Also, activation of protein kinase C results in a negative feedback loop, wherein it phosphorylates specific serine residues leading to the inactivation of KIT.

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP304(78799) with a 97.0% conversion rate.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
80716view15:23, 30 June 2015Mkutmonhomology conversion
67423view10:59, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
63453view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40587view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35758view00:04, 13 February 2010AlexanderPico
33825view00:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32485view12:44, 17 August 2009MaintBotFixed text labels
31183view19:28, 13 August 2009MaintBotFixed text labels
30573view22:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
BADProteinENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:572
BCL2RnaENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
BTKProteinENSBTAG00000019250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:695
CBLProteinENSBTAG00000006817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867
CRKProteinENSBTAG00000005665 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
CRKLProteinENSBTAG00000045548 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
DOK1ProteinENSBTAG00000018579 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1796
EP300ProteinENSBTAG00000016198 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
FOSRnaENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXO3ProteinENSBTAG00000011234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2309
FYNProteinENSBTAG00000011851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GAB2Protein
GRB10ProteinENSBTAG00000017086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2887
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
GRB7ProteinENSBTAG00000017366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2886
HRASProteinENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
INPP5DProteinENSBTAG00000020173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3635
JAK2ProteinENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JUNBRnaENSBTAG00000012046 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3726
KITProteinENSBTAG00000002699 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3815
KITLGProteinENSBTAG00000017549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254
LYNProteinENSBTAG00000020034 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4067
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3ProteinENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK8ProteinENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPTProteinENSBTAG00000017512 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4137
MATKProteinENSBTAG00000006619 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4145
MITFProteinENSBTAG00000006679 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4286
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PLCG1ProteinENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
PRKCAProteinENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCBProteinENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PTPN11ProteinENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
PTPN6ProteinENSBTAG00000020294 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5777
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RPS6ProteinENSBTAG00000014449 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
RPS6KA1ProteinENSBTAG00000014447 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
RPS6KA3ProteinENSBTAG00000017639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6197
RPS6KB1ProteinENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
SH2B2ProteinENSBTAG00000009691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10603
SHC1ProteinENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SNAI1RnaENSBTAG00000014554 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6615
SNAI2RnaENSBTAG00000013227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6591
SOCS1ProteinENSBTAG00000004386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
SOCS6ProteinENSBTAG00000017412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9306
SOS1ProteinENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AProteinENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BProteinENSBTAG00000010125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
TBX2RnaENSBTAG00000014278 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6909
TECProteinENSBTAG00000005062 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7006
VAV1ProteinENSBTAG00000039160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409

Annotated Interactions

No annotated interactions
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