181, 5, 8-11, 14...126, 1218181221, 5, 8-11, 14...61, 5, 8-11, 14...18218151526, 12121, 5, 8-11, 14...2184183, 7, 11, 13, 16181, 5, 8-11, 14...6, 1246, 121818181, 5, 8-11, 14...41, 5, 8-11, 14...18186, 12DNA damage sourceDNA repair and damage preventionG2–MCheckpointG2/M transitionCell-cyclearrestCell survivalG1/S transitionChange in the Cell conditionROSUCN-017-hydroxystaurosporineReplication stressDouble-strand breaksCell-cycle progressionChromatinremodellingDNA adductGene productAlkylating agentsROSEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)Caption:MetaboliteBlocked transcriptionSenescenceBulky DNA lesionExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsInhibitionApoptosisDNA repairG2/M checkpoint arrestEnd of pathwaySpecialized:Somatic hypermutaionV(D)J recombinationClass switchingChromatin alterationActivationBlocked replicationE2F1CCNB3CDKN1BRB1TLK1TP53AIP1BIDE2F1DDB2CASP8PMLCCND3CHEK1MRE11TNFRSF10BGADD45APRKDCATMPMAIP1RAD50RAD1CHEK2CDC25CCDK2GADD45ACCNB1c-MycCCND1ABL1CDK6CDC25ACCNE1FASPIDDAPAF1TP53CCNE2RRM2BATRGADD45GFANCD2CaffeineCASP9BAXCDKN1AGADD45BEstradiolGADD45GCCNB2RAD52ATRIPCCND2CYCSGADD45BNBNRAD9ACREBH2AFXCASP3SESN1HUS1RPA2SFNRAD51CDC2SMC1ARFCRB1TLK2CDK5RAD17BBC3CDK4BRCA1