53DEPTOR427611444444LegendMalfunction of epigenetic machineryglucosePDGFRAProtein TranslationFatty Acid SynthesisACACAEGFRFASNSTAT3FLT1ENPP3GlycolysisCAMK1HK3AMPKEFCAB3Cell proliferationKCNJ2PAngiogenesisAKT1MLST8SQSTM1MTORRPTORTSC1p300GRB10MePI3KMIR21MeRTKsPTENGLUT1VEGFARHEBVHLHIF1AHIF1BPBRM1SETD2BAP1KDM5CH2UbH3H3MeMeH2Activation of PI3K-mTOR pathwayTSC2HIF1BHIF1ACell migrationand invasionHIF1AHIF1BHIF1AUbPDGFBTGFB1TGFB2TGFB3CBPp300CBPAKT1S1ACACBACLYMDH1ME1HK1HK2GPIPFKLPFKPPFKMALDOAALDOBALDOCTPI1GAPDHPGK1PGK2PGM1PGM2ENO1ENO2ENO3PHGDHPSAT1PSPHSHMT1SHMT2SDSSDSLPKLRLDHALDHBLDHDLDHCPKMHIF1APKM2PDGFRBKDRBHLHE41CDH13CEP290KSR1PGBD5PLOD2SSPNRAPGEF5ZEB1TOX2Activating mutationInactivating mutationProteasome degradationNucleus