1MitochondriaLysosomeDNA damageLipid peroxidationNECROSOMELowered pHNecroptosisTRADDFADDGlutaminolysisArachidonic acidRIPK1SMasesGe NPPAMPscPLA2Nec-1CalpainsCalciumCASP8TNFR1ATPIronCeramideTRIFTNFJNKROSlipoxygenasePARP1RIPK32TLRsFerritinLabile iron poolGlycogenolysisGlycolysisIron