217013731, 67, 137, 25726, 69, 93, 101, 142...131203, 2082, 20, 190, 223235, 17638, 2468193, 2498, 211, 23850106355320, 56, 192, 217226EnzymesCa++ metabolismNegative EffectLeukotriene metabolismMetabolic stressConversionis composed ofSelenoproteinsFrom intracellular part to the plasmaInflammation and immune responseBiomarker forCofactor conversionSelenium statusBindingNecessary stimulationTryptophan metabolismLipoprotein melabolismOxidative stressProcess or metabolism involved in Se PathwayStatusGlycogenesisStimulationProstaglandins metabolismCofactorsMicronutrientsReactionLipid peroxidationOther proteinsMetabolitesProtein tyrosine nitrationOverarching processCatalysisTranscription factorCleavageLEGENDInhibitionIntracellularNAD+ metabolismGlutathione metabolismER protein foldingDNA oxidationFolate metabolismPlasmaPGG2Lipoxin A4COX1F2-IsoprostaneLipoxin B48-Isoprostaglandin F2aPGE2Lipoxin B4EPACOX2Lipoxin A4PGE2ALAPGD2PGH2Arachidonic acidALADGLAPGE1PGH3NFkB2MDAPGD2Linoleic acidDPAPGF2aPGE1PGE3PGF2aRELA8-Isoprostaglandin F2aDHAEPAMDAPGI2DPAThromboxane B2Linoleic acidThromboxane A2Arachidonic acida-TocopherolF2-Isoprostanea-TocopherolDHANFkB1Thromboxane B2PGI2636316983, 183, 219, 233, 245...24922286111, 15986, 20922271757571, 7563111, 24062, 7222263391118662, 86, 121, 165, 169...7119, 11111111183, 219, 233, 245, 266180, 25271, 75121, 180, 222, 252, 26562, 728662, 72249180, 25222239, 102, 11111112186, 121, 169, 25326511139Kynurenine176MTR113, 131TRXR1CBS113, 185IodineIodine4646KMO17615-HETE15-HETER-Triiodothyronine (rT3)5-HPETE5,6-EpoxytetraeneTriiodothyronine (T3)R-Triiodothyronine (rT3)5-HETEThyroxine (T4)Triiodothyronine (T3)Thyroxine (T4)5-HETE46, 16446, 1646363, 26552, 69, 26598, 16426552, 69, 26598, 16498, 16452, 69, 26546, 164NADP+MPOMPOCatalase14, 25, 223, 2412232, 66Uric acid91, 203CysteinePLGGGT1tPAPLGFactor VIIPAI-1ThrombinPAI-1tPAFactor VIIThrombin10310360, 163103103122, 163129122, 16310310360, 163GPX 4TRXR2Xantine oxidase91, 135PRDX5H2O2ALOX15BALOX5151, 26563, 165, 219, 234, 259CopperUric acid91, 203Vitamin B1232, 1335,10-Methylene-THFSelR190, 224Tryptophan35, 1765-methyl-THFSOD3PRDX1RFK214H2OGPX 3NiacinamideCTH113PNPO152Heme2, 66, 81, 102, 185NADPHLipoic acid67ManganeseFAD221Methionine sulfoxide190Dehydroascorbic acid218, 257Leukotriene A4239, 242NADPHFAD221THFHydroxykynurenine176Folic acid131NADP+NADPHSeleniumSelenium8888SelKSep1520, 90, 192256GPX 6GSH244Nicotinamidase35Calcium239Methionine190ManganeseNADPHFolic acid131FMN221SelenideSelenocysteineSelenophosphate31, 16431, 16431, 164CysteineLeukotriene C4Leukotriene C4129, 239GPX 326Dehydroascorbic acid257GPX 2SelP160Trx-S267, 137, 257Ascorbic acid218Lipoic acid67PRDX4GPX 1NADP+HomocysteineRNSROS2, 8, 16, 28, 40...2, 50NADPHVitamin B1232, 133MTHFR131Homocysteine60DIO1SelNSelHSelPSelISPS2DIO3SelMSelSDIO2SelVSelTSelO164, 2157070, 211, 23824, 49, 160, 17256, 107, 1457046, 164, 2626, 40, 217708, 7046, 16446, 16453, 125SOD1Pyridoxal 5'-phosphate176SerineIron239HypoxanthinePRDX3GSR130SAA1HDL-CCholesterolAPOBACTVLDL-TAGHDL-CLDLAPOA1HDL/APOA1APOBVLDLHDL/SAALDLRHDLVLDL/APOBCholesterolSAA4ACTABCA1oxLDLHDLFMNSAA3oxLDLSRB1APOA1SAA2TAGLDLVLDLVLDL-TAGAPOA1-NO2TyrTAG45, 64, 24624624610824647, 110, 17864, 24664, 246178108246108, 14864, 24622110810824645, 24624645108108, 14814, 38, 93, 101, 18310824614, 38, 93, 101, 18319124610864, 24614, 38, 93, 10124647, 110, 17814, 38, 93, 101O2249Pyridoxal 5'-phosphate176FAD8-OHdG8-OHdG226226221PRDX2ADPLeukotriene D4Leukotriene D4129ChlorineCopperChlorineCystathionineFAD221SOD2Dihydrolipoate28, 67SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B4242239, 242Quinolinic Acid35, 176PMPNOHNO2HOClNOO3NO225, 24125, 241NADP+GSH53, 242, 244IL6FibrinsICAM-1FLAPCCL2D-dimerCRPINSRsICAM-1IL1BD-dimerIL10ALBINSFibrinFibrinogenHBBIFNgALBIL1BINSFibrinogenTNFaIL10TNFaHbA1cHbA1cCCL2IL6IFNgHBA11867, 49, 2622465, 106, 206, 23565, 106, 148, 206, 23565, 235103, 1557, 144, 2131077, 144, 21393, 144, 183, 204186, 204, 26216, 241571577, 16, 107, 175103, 122262264103, 1222415716, 2423426426249, 107, 175103, 155186107157SelW127, 168, 244Riboflavin194SOD3208TRXR1137Ascorbate218, 257O2-XanthineCalcium239Kynureninase176Methionine190ADPTrx-(SH)267, 137ONOO-/ONOOHNitrotyrosineNitrotyrosine5050ATPLeukotriene E4Leukotriene E4129FructosamineLeukotriene F4GlucoseFructosamine82, 129106, 157264264Iron239HypoxanthineTRXR3FLAD1123, 214Ascorbic acid83, 218, 266