22026
Entrez Gene
20183
Entrez Gene
11819
Entrez Gene
Nr5a2
13865
Entrez Gene
20182
Entrez Gene
Nr1h3
Esr1
20181
Entrez Gene
21907
Entrez Gene
13982
Entrez Gene
Mus musculus
Nuclear Receptors
This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP170&oldid=21037 WP170(r21037)] with a 100% conversion rate. (HomologyConvert)
Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis.
Source: Wikipedia ([[wikipedia:Nuclear_receptor]]) (WikiPathways-description)
Molecular Function (WikiPathways-category)
13983
Entrez Gene
26379
Entrez Gene
21834
Entrez Gene
21833
Entrez Gene
Nr2c2
19401
Entrez Gene
13864
Entrez Gene
Ppard
Thrb
Rara
Pgr
19883
Entrez Gene
26563
Entrez Gene
11614
Entrez Gene
353187
Entrez Gene
Rarg
Ar
Nr2e1
Ppara
Nr2f6
Rxra
Thrb
Esrra
19016
Entrez Gene
19015
Entrez Gene
22337
Entrez Gene
Nr5a1
15378
Entrez Gene
22260
Entrez Gene
22259
Entrez Gene
Nr3c1
Rarb
Ror1
19885
Entrez Gene
Pparg
Nr2f2
Nr0b1
Thra
Rxrg
Nr1h2
Hnf4a
Rorc
Nr4a1
Esrrb
Rarg
Pparg
Nr2f1
218772
Entrez Gene
19411
Entrez Gene
19013
Entrez Gene
26380
Entrez Gene
14815
Entrez Gene
Vdr
Esr2
15370
Entrez Gene
Nr1d2
Nr4a2
18667
Entrez Gene
11835
Entrez Gene
Rora
26423
Entrez Gene
18227
Entrez Gene
12355
Entrez Gene
Nr1i2
Rxrb
18171
Entrez Gene
Nr1i3
26424
Entrez Gene