22026 Entrez Gene 20183 Entrez Gene 11819 Entrez Gene Nr5a2 13865 Entrez Gene 20182 Entrez Gene Nr1h3 Esr1 20181 Entrez Gene 21907 Entrez Gene 13982 Entrez Gene Mus musculus Nuclear Receptors This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP170&oldid=21037 WP170(r21037)] with a 100% conversion rate. (HomologyConvert) Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]]) (WikiPathways-description) Molecular Function (WikiPathways-category) 13983 Entrez Gene 26379 Entrez Gene 21834 Entrez Gene 21833 Entrez Gene Nr2c2 19401 Entrez Gene 13864 Entrez Gene Ppard Thrb Rara Pgr 19883 Entrez Gene 26563 Entrez Gene 11614 Entrez Gene 353187 Entrez Gene Rarg Ar Nr2e1 Ppara Nr2f6 Rxra Thrb Esrra 19016 Entrez Gene 19015 Entrez Gene 22337 Entrez Gene Nr5a1 15378 Entrez Gene 22260 Entrez Gene 22259 Entrez Gene Nr3c1 Rarb Ror1 19885 Entrez Gene Pparg Nr2f2 Nr0b1 Thra Rxrg Nr1h2 Hnf4a Rorc Nr4a1 Esrrb Rarg Pparg Nr2f1 218772 Entrez Gene 19411 Entrez Gene 19013 Entrez Gene 26380 Entrez Gene 14815 Entrez Gene Vdr Esr2 15370 Entrez Gene Nr1d2 Nr4a2 18667 Entrez Gene 11835 Entrez Gene Rora 26423 Entrez Gene 18227 Entrez Gene 12355 Entrez Gene Nr1i2 Rxrb 18171 Entrez Gene Nr1i3 26424 Entrez Gene