Ensembl ENSG00000101460 Ensembl ENSG00000097033 Ensembl ENSG00000101844 Ensembl ENSG00000144848 ATG10 IR ULK2 Ensembl ENSG00000198382 Ensembl ENSG00000145782 ATG4 Ensembl ENSG00000057663 Homo sapiens Cellular Process (WikiPathways-category) Programmed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can result in genetically programmed cell death. Carbon nanotubes, PAMAMs, and iron oxide nanoparticles were reported to trigger autophagic cell death through the perturbation of the mTOR pathway, while gold nanoparticles may induce autophagy blockade through lysosomal impairment. (WikiPathways-description) Nanoparticle triggered autophagic cell death Ensembl ENSG00000085978 ATG12 NanoParticle Ontology NPO_401 Uniprot P01308 Ensembl ENSG00000171105 Ensembl ENSG00000165699 Ensembl ENSG00000197548 p150 VMP1 PI3KCIII 2011 Yu L Jin S Liang XJ Ma X Wu Y Tian Y Zhao Y Zhang X ACS Nano PubMed 21974862 Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. Au NP ATG3 ATG16L Ensembl ENSG00000177169 Ensembl ENSG00000152348 Ensembl ENSG00000062716 Atg14L LC3-II Ensembl ENSG00000181652 Ensembl ENSG00000110497 Ensembl ENSG00000126775 Ensembl ENSG00000167670 Ensembl ENSG00000103197 Ensembl ENSG00000126581 PI3KCIII Carbon nanotube 3-MA NanoParticle Ontology NPO_606 TCS-1 ATG7 Bif1 UVRAG ATG9 Ambra1 LC3-I AMPK TCS-2 Beclin1 BCL-2 Ensembl ENSG00000171791 PubChem-compound 1673 PI3k/AKT Insulin Beclin1 p150 2012 Chauhan LK Patil G Ahmad I Mohammad A Naqvi SA Khan MI Biomaterials PubMed 22098780 Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. ATG5 Ensembl ENSG00000083290 NanoParticle Ontology NPO_965 2011 Yang P Zhang YX Guo F Wang YG Zhang GG Jiang CY Sun Y Li CG Yang N Zhang YL Zhao Y Liu HL Liu XQ Cell Death Dis PubMed 21593791 A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. ULK1 NanoParticle Ontology NPO_273 PAMAM PI3KCIII 2009 Wang H Liu H Rao S Jiang C Xu H Guo F Guo C Miao Y Deng J Li B Chen X Sun Y Meng J Li L Li C Li D Zhang Y J Mol Cell Biol PubMed 19516051 PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. FeO NP