3.5.4.16
Enzyme Nomenclature
3.6.1.n4
3.6.1.n4
Enzyme Nomenclature
CHEBI:29987
ChEBI
THF and one carbon derivative
ATP
tetrahydrofolate
6.3.2.17
aminodeoxychorismate
3.5.4.16
p-aminobenzoate diffusion
Zea mays
Vitamin B9 (folate) biosynthesis pathway
Tetrahydrofolate (THF) acts as a carrier for one-carbon units and, less often, as an electron donor. THF contains pterin, p-aminobenzoate, and glutamate moieties. The pterin is made in the cytosol from GTP, p-aminobenzoate is made from chorismate in plastids, and the two are coupled together in mitochondria to give dihydropteroate. Glutamylation and reduction steps in mitochondria then yield THF (Hanson and Gregory, 2011; Ravanel et al., 2011). THF and its one-carbon derivatives (collectively termed folates) occur mainly as polyglutamates; these have a short polyglutamyl tail that can be added in mitochondria, plastids, or cytosol. Folate polyglutamates can be imported into vacuoles, where the polyglutamyl tail can be removed by γ-glutamylhydrolase. p-Aminobenzoate can be converted to its glucose ester in the cytosol, and imported into vacuoles. (WikiPathways-description)
Metabolic Process (WikiPathways-category)
folate polyglutamate
2.7.6.3
Enzyme Nomenclature
GRMZM2G095806
GRMZM2G062420
Gramene Maize
p-aminobenzoate
GRMZM2G416386
Gramene Maize
hydroxymethyldihydropterin pyrophosphate
GRMZM2G304915
5815
Chemspider
1.5.1.3
Enzyme Nomenclature
folate polyglutamate
82572
Chemspider
6.3.2.12
Enzyme Nomenclature
ATP
p-aminobenzoate
PO4
dihydroneopterin monophosphate phosphatase
glutamate
GRMZM2G106376
dihydrofolate
dihydropteroate
165
Chemspider
2.5.1.15
Enzyme Nomenclature
pterin glycosides
6.3.2.17
ADP
4.1.2.25
Enzyme Nomenclature
GRMZM5G840435
GRMZM2G015588
Gramene Maize
dihydromonapterin
GRMZM2G106376
Gramene Maize
HCOOH
GRMZM2G393334
UDP-glucose:pterin glycosyltransferase
folate monoglutamate transporter
6.3.2.17
Enzyme Nomenclature
2.7.6.3
ATP
6.3.2.12
THF and one carbon derivative
GRMZM2G095955
glutamate
756
PubChem-compound
5957
PubChem-compound
GRMZM2G095579
6.3.2.17
GRMZM2G073429
aminodeoxychorismate
GRMZM2G139880
UDP
GRMZM2G469469
GRMZM2G421493
GRMZM2G169481
ADP
pterin transporter
p-aminobenzoate
dihydromethyldihydropterin pyrophosphate
1.5.1.3
GRMZM2G416386
folate polyglutamate
ADP
2.6.1.85
folate transporter
GRMZM2G069596
p-aminobenzoate glucose ester
THF and one carbon derivative
GRMZM2G095806
folate polyglutamate
PO4
Uridine 5'-diphosphate glucose (UDPG)
PPi
p-aminobenzoate diffusion
THF and one carbon derivative
pyruvate
glutamate
THF and one carbon derivative
AMP
dihydroneopterin triphosphate
ATP
GTP
NADPH
4.1.2.25
dihydroneopterin, dihydromonapterin
GRMZM2G062420
glutamine
dihydroneopterin monophosphate
folate transporter
GRMZM2G087103
glycolaldehyde
dihydroneopterin
ATP
GRMZM5G869779
PPi
hydromethyldihydropterin transporter
3.4.19.9
p-aminobenzoate glucose ester
folate transporter
glutamate
p-aminobenzoate glucose ester transporter
GRMZM2G363554
2.5.1.15
GRMZM2G069596
Gramene Maize
ATP
folate polyglutamate transporter
GRMZM2G095579
Gramene Maize
GRMZM2G095806
Gramene Maize
glutamate
GRMZM2G087103
Gramene Maize
GRMZM2G169481
Gramene Maize
2.6.1.85
Enzyme Nomenclature
GRMZM2G344993
AMP
UDP-glucose:p-aminobenzoate glucosyltransferase
glutamate
GRMZM2G304915
Gramene Maize
GRMZM2G072608
Gramene Maize
GRMZM2G421493
Gramene Maize
GRMZM2G005990
Gramene Maize
GRMZM2G005990
GRMZM2G139880
Gramene Maize
2.5.1.15
2.7.6.3
PO4
NADP
3.4.19.9
Enzyme Nomenclature
hydromethyldihydropterin
GRMZM2G015588
GRMZM2G095955
Gramene Maize
GRMZM5G869779
Gramene Maize
GRMZM2G393334
Gramene Maize
GRMZM2G344993
Gramene Maize
H2O
GRMZM2G363554
Gramene Maize
ADP
GRMZM2G027603
4.1.3.38
GRMZM2G084181
GRMZM2G027603
Gramene Maize
GRMZM2G072608
GRMZM2G084181
Gramene Maize
dihydropteroate
PO4
GRMZM5G840435
Gramene Maize
GRMZM2G469469
Gramene Maize
GRMZM2G073429
Gramene Maize
hydromethyldihydropterin
4.1.3.38
Enzyme Nomenclature