Metabolic ProcessThe [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both [[wikipedia:Albert_Szent-Gyorgyi|Albert Szent-Gyorgyi]] and [[wikipedia:Hans_Krebs|Hans Krebs]].
Source: Wikipedia ([[wikipedia:citric_acid_cycle]])e64The ChEBI ID with the correct charge is: 37565The ChEBI ID with the correct charge is: 58189The ChEBI ID with the correct charge is: 57945The ChEBI ID with the correct charge is: 57945The ChEBI ID with the correct charge is: 16383The ChEBI ID with the correct charge is: 15562Not all metabolic pathways of amino acids are connected to the TCa cycle.d25The ChEBI ID with the correct charge is: 30031The ChEBI ID with the correct charge is: 30616The ChEBI ID with the correct charge is: 57287The ChEBI ID with the correct charge is: 57288The ChEBI ID with the correct charge is: 57287The ChEBI ID with the correct charge is: 456216The ChEBI ID with the correct charge is: 57783The ChEBI ID with the correct charge is: 57287Type your comment hereThe ChEBI ID with the correct charge is: 57945The ChEBI ID with the correct charge is: 57292eada4ded6af4be3b56af4f8cb72ea0a20c21c9ec21c9ee8acitrate cycle pathwayPW:0000026Pathway Ontology3724458PubMedActivity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.Metabolism1986Gabriel JLZervos PRPlaut GW10672230PubMedThe alpha-ketoglutarate dehydrogenase complex.Ann N Y Acad Sci1999Sheu KFBlass JP7730304PubMedIsotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.J Biol Chem1995Des Rosiers CDi Donato LComte BLaplante AMarcoux CDavid FFernandez CABrunengraber H3052428PubMedPhysiological roles of nicotinamide nucleotide transhydrogenase.Biochem J1988Hoek JBRydström J9765290PubMedCharacterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.J Biol Chem1998Johnson JDMuhonen WWLambeth DO12234803PubMedReverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.Am J Physiol Heart Circ Physiol2002Comte BVincent GBouchard BBenderdour MDes Rosiers Cclassic metabolic pathwayPW:0000002Pathway OntologyTCA cyclePW:0000026Pathway Ontology8506365PubMedIdentification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.Proc Natl Acad Sci U S A1993Liu TCKim HArizmendi CKitano APatel MS8187868PubMedProton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.FEBS Lett1994Sazanov LAJackson JB15234968PubMedExpression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.J Biol Chem2004Lambeth DOTews KNAdkins SFrohlich DMilavetz BI7961626PubMedReversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.J Biol Chem1994Des Rosiers CFernandez CADavid FBrunengraber H949837PubMedUrinary organic acids in man. I. Normal patterns.Clin Chem1976Lawson AMChalmers RAWatts RW7060582PubMedCitrate synthesis in intact rat-liver mitochondria is irreversible.Eur J Biochem1982Greksák MLopes-Cardozo Mvan den Bergh SG13018271PubMedThe conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.Biochem J195213018271PubMedThe conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.Biochem J1952Krebs HAHolzach OPubMedThe Role of Citric Acid in Intermediate Metabolism in Animal Tissues.Enzymologia1937Krebs, H. A.Johnson, W. A.7730305PubMedModeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.J Biol Chem1995Fernandez CADes Rosiers C