This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.
If it is not mentioned different, the processes take place in the cell cytoplasma.
The goal of this first pathway is to give an overview of the most importabt gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arrangedd5fe6fd5fe6fe6fa35c56e48d50b66ac5b4fa1bdf4d5fe6fa35d5fefbc48d5fc48e6fe6fa35bf4bf4c48bf4c48d5fd5fefba35d5fd5fd5fe48dabaf9c04da1e6fa35c56e48d50b66ac5b4fa1bdf4d5fc56e48d50b66ac5b4fa1bdf4c56e48d50b66ac5b4fa1bdf4c56e48d50b66ac5b4fa1bdf4c56e48d50b66ac5b4fa1bdf4c56e48d50b66ac5b4fa1bdf4e6fa35d5fd5f15343279PubMedTranscription - guarding the genome by sensing DNA damage.Nat Rev Cancer2004Ljungman MLane DP15668327PubMedChromosomal instability in oral cancer cells.J Dent Res2005Reshmi SCGollin SM14993903PubMedTargeting the checkpoint kinases: chemosensitization versus chemoprotection.Nat Rev Cancer2004Zhou BBBartek J16921403PubMedRegulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.Nat Rev Mol Cell Biol2006Gil JPeters G19111245PubMedConcurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?Lancet Oncol2009Chargari CToillon RAMacdermed DCastadot PMagn� N17568790PubMedCDC25 phosphatases in cancer cells: key players? Good targets?Nat Rev Cancer2007Boutros RLobjois VDucommun B15688066PubMedp53: traffic cop at the crossroads of DNA repair and recombination.Nat Rev Mol Cell Biol2005Sengupta SHarris CC14634621PubMedThe Bcl-2 family: roles in cell survival and oncogenesis.Oncogene2003Cory SHuang DCAdams JM17943134PubMedThe impact of a negligent G2/M checkpoint on genomic instability and cancer induction.Nat Rev Cancer2007L�brich MJeggo PA15719025PubMedThe role of BH3-only proteins in the immune system.Nat Rev Immunol2005Strasser A17128209PubMedRegulating the p53 pathway: in vitro hypotheses, in vivo veritas.Nat Rev Cancer2006Toledo FWahl GM16805667PubMedSurviving the breakup: the DNA damage checkpoint.Annu Rev Genet2006Harrison JCHaber JE17768402PubMedEmergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.Nat Rev Genet2007Wang W18004398PubMedCHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?Nat Rev Cancer2007Antoni LSodha NCollins IGarrett MD17060944PubMedPolycomb silencers control cell fate, development and cancer.Nat Rev Cancer2006Sparmann Avan Lohuizen M15545627PubMedLiving with or without cyclins and cyclin-dependent kinases.Genes Dev2004Sherr CJRoberts JM15339658PubMedWagging the dogma; tissue-specific cell cycle control in the mouse embryo.Cell2004Pagano MJackson PK17380161PubMedp53 in health and disease.Nat Rev Mol Cell Biol2007Vousden KHLane DP