Cellular ProcessStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.
Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]
c3aa6b10770267PubMedDirect effects of statins on cells primarily involved in atherosclerosis.Hypertens Res2000Chen HIkeda UShimpo MShimada K9106493PubMedMicrosomal triglyceride transfer protein.Biochim Biophys Acta1997Wetterau JRLin MCJamil Hcardiovascular system diseaseDOID:1287Diseasestatin drug pathwayPW:0000724Pathway OntologyhepatocyteCL:0000182Cell Type