Eicosanoid synthesis (WP972)
Bos taurus
In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric WeitzCited In
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Organism
Bos taurusCommunities
Annotations
Pathway Ontology: eicosanoid biosynthetic pathway inflammatory response pathway
Cell Type Ontology: epithelial cell
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| 5-HETE | Metabolite | cas:70608-72-9 | |
| 5-HPETE | Metabolite | hmdb:HMDB0001193 | |
| Prostaglandin H2 | Metabolite | hmdb:HMDB0001381 | |
| Leukotriene D4 | Metabolite | hmdb:HMDB0003080 | |
| Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
| Prostaglandin I2 | Metabolite | hmdb:HMDB0001335 | |
| Prostaglandin D2 | Metabolite | hmdb:HMDB0001403 | |
| Leukotriene A4 | Metabolite | hmdb:HMDB0001337 | |
| Prostaglandin F2a | Metabolite | hmdb:HMDB0001139 | |
| Leukotriene C4 | Metabolite | hmdb:HMDB0001198 | |
| Leukotriene E4 | Metabolite | hmdb:HMDB0002200 | |
| 12-HETE | Metabolite | cas:70608-72-9 | |
| 15-HETE | Metabolite | cas:70608-72-9 | |
| Thromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
| Arachidonic acid | Metabolite | hmdb:HMDB0001043 | |
| Leukotriene B4 | Metabolite | hmdb:HMDB0001085 | |
| 12-HPETE | Metabolite | cas:71030-35-8 | |
| 15-HPETE | Metabolite | cas:70981-96-3 | |
| Prostaglandin E2 | Metabolite | cas:363-24-6 | |
| ALOX5AP | GeneProduct | ensembl:ENSBTAG00000013201 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:241 |
| PTGDS | GeneProduct | ensembl:ENSBTAG00000015074 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5730 |
| PTGES2 | GeneProduct | ensembl:ENSBTAG00000016218 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80142 |
| DPEP1 | GeneProduct | ensembl:ENSBTAG00000033326 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1800 |
| PTGIS | GeneProduct | ensembl:ENSBTAG00000017537 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5740 |
| PLA2G2A | GeneProduct | ensembl:ENSBTAG00000005759 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5320 |
| ALOX5 | GeneProduct | ensembl:ENSBTAG00000020319 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:240 |
| PNPLA3 | GeneProduct | ensembl:ENSBTAG00000045746 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PNPLA3 |
| TBXAS1 | GeneProduct | ensembl:ENSBTAG00000020225 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6916 |
| PTGS1 | GeneProduct | ensembl:ENSBTAG00000006716 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5742 |
| GGT1 | GeneProduct | ensembl:ENSBTAG00000046900 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2678 |
| PLA2G6 | GeneProduct | ensembl:ENSBTAG00000014015 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8398 |
| ALOX15 | GeneProduct | ensembl:ENSBTAG00000011990 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:246 |
| ALOX15B | GeneProduct | ensembl:ENSBTAG00000008779 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:247 |
| PTGES | GeneProduct | ensembl:ENSBTAG00000019453 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9536 |
| ALOX5 | GeneProduct | ensembl:ENSBTAG00000020319 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:240 |
| LTA4H | GeneProduct | ensembl:ENSBTAG00000016415 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4048 |
| PGHS-2 | GeneProduct | ensembl:ENSBTAG00000014127 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743 |
| LTC4S | GeneProduct | ensembl:ENSBTAG00000009737 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4056 |
| ALOX15 | GeneProduct | ensembl:ENSBTAG00000011990 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:246 |
| ALOX5AP | GeneProduct | ensembl:ENSBTAG00000013201 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:241 |
| PNPLA8 | GeneProduct | ensembl:ENSBTAG00000024387 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50640 |
| ALOX12 | GeneProduct | ensembl:ENSBTAG00000021933 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:239 |
References
- Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia