Matrix metalloproteinases (WP942)

Pan troglodytes

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]
last edited


Thomas Kelder , Daniela Digles , and Eric Weitz

Cited In

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Pathway Ontology: cell-extracellular matrix signaling pathway


Label Type Compact Identifier Comment
MMP2 GeneProduct ncbigene:454094
MMP9 GeneProduct ncbigene:458294
MMP7 GeneProduct ncbigene:451509
MMP12 GeneProduct ncbigene:451512
MMP20 GeneProduct ncbigene:740407
MMP10 GeneProduct ncbigene:740658
MMP3 GeneProduct ncbigene:451511
MMP11 GeneProduct ncbigene:458701
MMP19 GeneProduct ncbigene:746523
MMP14 GeneProduct ncbigene:742887
MMP15 GeneProduct ncbigene:467988
MMP16 GeneProduct ncbigene:736322
MMP17 GeneProduct ncbigene:452375
MMP24 GeneProduct ncbigene:469925
TIMP3 GeneProduct ncbigene:458784
TIMP4 GeneProduct ncbigene:460176
TNF GeneProduct ncbigene:744399
MMP26 GeneProduct ncbigene:450977
MMP27 GeneProduct ncbigene:466763
TCF20 GeneProduct ncbigene:458876
MMP1 GeneProduct ncbigene:451510
MMP8 GeneProduct ncbigene:740516
MMP13 GeneProduct ncbigene:451513
MMP23B GeneProduct ncbigene:746857


  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia