Ketone bodies synthesis and degradation (WP898)
Pan troglodytes
Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]
Authors
Thomas Kelder , Egon Willighagen , Kristina Hanspers , Daniela Digles , Zhu.lu , and Eric WeitzCited In
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Organism
Communities
Annotations
Pathway Ontology: ketone bodies metabolic pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| Acetoacetyl-CoA | Metabolite | cas:1420-36-6 | |
| 3-Hydroxy-3-methylglutaryl-CoA | Metabolite | cas:1553-55-5 | |
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| 3-Hydroxy-butyrate | Metabolite | pubchem.compound:441 | |
| Acetoacetate | Metabolite | pubchem.compound:6971017 | |
| ACAT1 | GeneProduct | ncbigene:451528 | |
| HMGCS2 | GeneProduct | ncbigene:457169 | |
| HMGCL | GeneProduct | ncbigene:456624 | |
| OXCT1 | GeneProduct | ncbigene:737468 | |
| BDH1 | GeneProduct | ncbigene:460970 |
References
- Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia