Eicosanoid synthesis (WP854)

Pan troglodytes

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]
last edited


Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.




Pathway Ontology: eicosanoid biosynthetic pathway


Label Type Compact Identifier Comment
5-HPETE Metabolite hmdb:HMDB0001193
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Leukotriene D4 Metabolite hmdb:HMDB0003080
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Leukotriene A4 Metabolite hmdb:HMDB0001337
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Leukotriene C4 Metabolite hmdb:HMDB0001198
Leukotriene E4 Metabolite hmdb:HMDB0002200
Thromboxane A2 Metabolite hmdb:HMDB0001452
Arachidonic acid Metabolite hmdb:HMDB0001043
Leukotriene B4 Metabolite hmdb:HMDB0001085
ALOX5AP GeneProduct ncbigene:452520
PTGDS GeneProduct ncbigene:749402
PTGES2 GeneProduct ncbigene:464763
PTGIS GeneProduct ncbigene:458323
PLA2G2A GeneProduct ncbigene:456587
ALOX5 GeneProduct ncbigene:450428
TBXAS1 GeneProduct ncbigene:463774
PTGS1 GeneProduct ncbigene:464713
GGT1 GeneProduct ncbigene:470168
ALOX15 GeneProduct ncbigene:748294
ALOX15B GeneProduct ncbigene:455104
PTGES GeneProduct ncbigene:473071
ALOX5 GeneProduct ncbigene:450428
LTA4H GeneProduct ncbigene:452145
PTGS2 GeneProduct ncbigene:469616
LTC4S GeneProduct ncbigene:739986
ALOX15 GeneProduct ncbigene:748294
ALOX5AP GeneProduct ncbigene:452520
PNPLA8 GeneProduct ncbigene:472484
ALOX12 GeneProduct ncbigene:455242


  1. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia