Matrix metalloproteinases (WP823)

Gallus gallus

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]
last edited


Thomas Kelder , Daniela Digles , and Eric Weitz

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Gallus gallus



Pathway Ontology: cell-extracellular matrix signaling pathway


Label Type Compact Identifier Comment
MMP2 GeneProduct ncbigene:386583
MMP9 GeneProduct ncbigene:395387
MMP7 GeneProduct ncbigene:418983
MMP3 GeneProduct ncbigene:418981
MMP11 GeneProduct ncbigene:769489
MMP14 GeneProduct ncbigene:426253
MMP15 GeneProduct ncbigene:415629
MMP16 GeneProduct ncbigene:396116
MMP17 GeneProduct ncbigene:416801
MMP24 GeneProduct ncbigene:419141
TIMP2 GeneProduct ncbigene:374178
TIMP3 GeneProduct ncbigene:396483
TIMP4 GeneProduct ncbigene:768711
BSG GeneProduct ncbigene:770363
MMP28 GeneProduct ncbigene:417523
MMP27 GeneProduct ncbigene:395850
TCF20 GeneProduct ncbigene:417980
MMP1 GeneProduct ncbigene:418982
MMP13 GeneProduct ncbigene:772008
MMP23B GeneProduct ncbigene:419407


  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia