G protein signaling pathways (WP813)

Gallus gallus

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]
last edited


Thomas Kelder , Christine Chichester , Lauren J. Dupuis , and Eric Weitz

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Gallus gallus



Pathway Ontology: G protein mediated signaling pathway


Label Type Compact Identifier Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
PRKAR2B GeneProduct ncbigene:769420
GNG10 GeneProduct ncbigene:769603
PDE7B GeneProduct ncbigene:421692
ADCY3 GeneProduct ncbigene:422013
ADCY5 GeneProduct ncbigene:395340
GNG12 GeneProduct ncbigene:772239
GNG11 GeneProduct ncbigene:771999
AKAP8 GeneProduct ncbigene:426167
AKAP1 GeneProduct ncbigene:417668
PRKAR1B GeneProduct ncbigene:416446
GNAS GeneProduct ncbigene:419313
PRKCD GeneProduct ncbigene:415905
GNB3 GeneProduct ncbigene:427945
RCJMB04_23b22 GeneProduct ncbigene:427262
GNAO1 GeneProduct ncbigene:415698
PRKCB GeneProduct ncbigene:416567
GNA14 GeneProduct ncbigene:431611
AKAP5 GeneProduct ncbigene:428917
GNAZ GeneProduct ncbigene:770226
PDE8B GeneProduct ncbigene:427645
NRAS GeneProduct ncbigene:419885
GNG13 GeneProduct ncbigene:771014
PRKAR1A GeneProduct ncbigene:417438
GNA11 GeneProduct ncbigene:374077
PRKCH GeneProduct ncbigene:423518
PPP3CA GeneProduct ncbigene:395113
GNAI1 GeneProduct ncbigene:396368
CALM1 GeneProduct ncbigene:396523
PRKACB GeneProduct ncbigene:424542
PRKAR2A GeneProduct ncbigene:416062
GNB5 GeneProduct ncbigene:415417
KCNJ3 GeneProduct ncbigene:396369
AKAP7 GeneProduct ncbigene:426926
GNA13 GeneProduct ncbigene:417434
PDE1A GeneProduct ncbigene:424116
PDE1C GeneProduct ncbigene:420752
ADCY2 GeneProduct ncbigene:420935
GNAO1 GeneProduct ncbigene:415698
GNAL GeneProduct ncbigene:474379
RCJMB04_12k21 GeneProduct ncbigene:423302
PRKD3 GeneProduct ncbigene:421478
ADCY9 GeneProduct ncbigene:395339
AKAP6 GeneProduct ncbigene:423314
ADCY1 GeneProduct ncbigene:420788
AKAP13 GeneProduct ncbigene:415502
PDE8A GeneProduct ncbigene:415455
AKAP12 GeneProduct ncbigene:421634
RHOA GeneProduct ncbigene:395442
GNAI3 GeneProduct ncbigene:374097
AKAP11 GeneProduct ncbigene:418835
PRKCE GeneProduct ncbigene:421409
RCJMB04_6n13 GeneProduct ncbigene:419402
RCJMB04_5a10 GeneProduct ncbigene:417430
RCJMB04_16p24 GeneProduct ncbigene:424991
GNG5 GeneProduct ncbigene:424538
HRAS GeneProduct ncbigene:396229
PRKCZ GeneProduct ncbigene:419399
AKAP10 GeneProduct ncbigene:417612
GNAI1 GeneProduct ncbigene:396368
ADCY8 GeneProduct ncbigene:420328
ADCY7 GeneProduct ncbigene:415732
PDE4B GeneProduct ncbigene:424700
KRAS GeneProduct ncbigene:418207
PDE7A GeneProduct ncbigene:425199
AKAP9 GeneProduct ncbigene:395695
GNG4 GeneProduct ncbigene:771582
GNA12 GeneProduct ncbigene:769924
ITPR1 GeneProduct ncbigene:395412
SLC9A1 GeneProduct ncbigene:419580
GNAI2 GeneProduct ncbigene:396367


  1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia