Wnt signaling pathway (WP785)

Gallus gallus

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].
last edited


Thomas Kelder , Daniela Digles , Egon Willighagen , Lauren J. Dupuis , and Eric Weitz

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Gallus gallus



Pathway Ontology: Wnt signaling pathway


Label Type Compact Identifier Comment
DVL3 GeneProduct ncbigene:424949
RHOA GeneProduct ncbigene:395442
RAC1 GeneProduct ncbigene:395871
PLAU GeneProduct ncbigene:396424
PRKCB GeneProduct ncbigene:416567
PRKCH GeneProduct ncbigene:423518
GSK3B GeneProduct ncbigene:418335 MOUSE:KG38 MOUSE
APC GeneProduct ncbigene:415607
FZD3 GeneProduct ncbigene:395572
MAPK9 GeneProduct ncbigene:395983
CSNK1E GeneProduct ncbigene:378891
CCND1 GeneProduct ncbigene:396341
LDLR GeneProduct ncbigene:395103
FZD8 GeneProduct ncbigene:374059
RCJMB04_12k21 GeneProduct ncbigene:423302
WNT7A GeneProduct ncbigene:374168
WNT11 GeneProduct ncbigene:395562
RCJMB04_5a10 GeneProduct ncbigene:417430
JUN GeneProduct ncbigene:424673
FZD10 GeneProduct ncbigene:373885
FZD7 GeneProduct ncbigene:374060
PPP2R5C GeneProduct ncbigene:423460
WNT5B GeneProduct ncbigene:418154
CTNNB1 GeneProduct ncbigene:395964
WNT2 GeneProduct ncbigene:417769
PRKCE GeneProduct ncbigene:421409
WNT2B GeneProduct ncbigene:374243
SFRP4 GeneProduct ncbigene:420732
PAFAH1B1 GeneProduct ncbigene:374224
WNT6 GeneProduct ncbigene:395235
CCND3 GeneProduct ncbigene:419928
WNT5A GeneProduct ncbigene:395703
FZD1 GeneProduct ncbigene:374062
WNT16 GeneProduct ncbigene:427856
FZD6 GeneProduct ncbigene:378788
WNT4 GeneProduct ncbigene:395561
PPP2R5E GeneProduct ncbigene:423512
WNT3 GeneProduct ncbigene:395396
AXIN1 GeneProduct ncbigene:395786
FZD5 GeneProduct ncbigene:374112
WNT7B GeneProduct ncbigene:427937
RCJMB04_2d20 GeneProduct ncbigene:419416
RCJMB04_16p24 GeneProduct ncbigene:424991
WNT10A GeneProduct ncbigene:429040
MAPK10 GeneProduct ncbigene:422592
MYC GeneProduct ncbigene:420332
PRKCZ GeneProduct ncbigene:419399
CCND2 GeneProduct ncbigene:374047
FZD9 GeneProduct ncbigene:373886
FBXW2 GeneProduct ncbigene:417088
PRKCD GeneProduct ncbigene:415905
WNT16 GeneProduct ncbigene:427856
FZD2 GeneProduct ncbigene:374061


  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia