G protein signaling pathways (WP73)

Rattus norvegicus

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]
last edited


Nathan Salomonis , Bruce Conklin , Charles Redfern , Thomas Kelder , Christine Chichester , Lauren J. Dupuis , and Eric Weitz

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Rattus norvegicus



Pathway Ontology: G protein mediated signaling pathway


Label Type Compact Identifier Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
Prkar2b GeneProduct ncbigene:24679
Gng10 GeneProduct ncbigene:114119
Pde7b GeneProduct ncbigene:140929
Adcy3 GeneProduct ncbigene:64508
Adcy5 GeneProduct ncbigene:64532
Gng12 GeneProduct ncbigene:114120
Gng11 GeneProduct ncbigene:64199
Akap8 GeneProduct ncbigene:116633
Ppp3cc GeneProduct ncbigene:171378
Akap1 GeneProduct ncbigene:114124
Prkar1b GeneProduct ncbigene:25521
GNAS GeneProduct ncbigene:24896
Prkcd GeneProduct ncbigene:170538
Gnb3 GeneProduct ncbigene:60449
Pde4a GeneProduct ncbigene:25638
Pde1b GeneProduct ncbigene:29691
Gnaq GeneProduct ncbigene:81666
Gnao1 GeneProduct ncbigene:50664
Pde4d GeneProduct ncbigene:24627
Prkcb GeneProduct ncbigene:25023
Rras GeneProduct ncbigene:361568
Gna14 GeneProduct ncbigene:309242
Akap5 GeneProduct ncbigene:171026
Gnaz GeneProduct ncbigene:25740
Adcy4 GeneProduct ncbigene:54223
Pde8b GeneProduct ncbigene:309962
Nras GeneProduct ncbigene:24605
Gng13 GeneProduct ncbigene:685451
Gngt1 GeneProduct ncbigene:680149
Gnb2 GeneProduct ncbigene:81667
PRKAR1A GeneProduct ncbigene:25725
Gna11 GeneProduct ncbigene:81662
Prkch GeneProduct ncbigene:81749
Ppp3ca GeneProduct ncbigene:24674
Gnai1 GeneProduct ncbigene:25686
CALM1 GeneProduct ncbigene:24242
Prkacb GeneProduct ncbigene:293508
Prkar2a GeneProduct ncbigene:29699
Gnb5 GeneProduct ncbigene:83579
Kcnj3 GeneProduct ncbigene:50599
Plcb3 GeneProduct ncbigene:29322
Akap7 GeneProduct ncbigene:361458
Gna13 GeneProduct ncbigene:303634
Adcy6 GeneProduct ncbigene:25289
Akap3 GeneProduct ncbigene:312720
Pde1a GeneProduct ncbigene:81529
Pde1c GeneProduct ncbigene:81742
Adcy2 GeneProduct ncbigene:81636
Gnao1 GeneProduct ncbigene:50664
Gnal GeneProduct ncbigene:24611
Prkd1 GeneProduct ncbigene:85421
Prkd3 GeneProduct ncbigene:313834
ADCY9 GeneProduct ncbigene:302950
Akap6 GeneProduct ncbigene:64553
Adcy1 GeneProduct ncbigene:305509
Ppp3cc GeneProduct ncbigene:171378
AKAP13 GeneProduct ncbigene:293024
Gna15 GeneProduct ncbigene:89788
Pde8a GeneProduct ncbigene:308776
Akap12 GeneProduct ncbigene:83425
Rhoa GeneProduct ncbigene:117273
Akap4 GeneProduct ncbigene:79254
Gnai3 GeneProduct ncbigene:25643
Akap11 GeneProduct ncbigene:498549
Gngt2 GeneProduct ncbigene:690825
Prkcq GeneProduct ncbigene:85420
AKAP2 GeneProduct ncbigene:298024
Pde4c GeneProduct ncbigene:290646
Gng8 GeneProduct ncbigene:245986
Prkce GeneProduct ncbigene:29340
Gng7 GeneProduct ncbigene:58979
Prkcg GeneProduct ncbigene:24681
Gnb1 GeneProduct ncbigene:24400
Prkca GeneProduct ncbigene:24680
Prkci GeneProduct ncbigene:84006
Gng5 GeneProduct ncbigene:79218
Gng3 GeneProduct ncbigene:114117
Hras GeneProduct ncbigene:293621
Prkcz GeneProduct ncbigene:25522
Arhgef1 GeneProduct ncbigene:60323
Akap10 GeneProduct ncbigene:360540
Gnai1 GeneProduct ncbigene:25686
Adcy8 GeneProduct ncbigene:29241
Adcy7 GeneProduct ncbigene:84420
Prkaca GeneProduct ncbigene:25636
Pde4b GeneProduct ncbigene:24626
Kras GeneProduct ncbigene:24525
Pde7a GeneProduct ncbigene:81744
Akap9 GeneProduct ncbigene:246150
GNG4 GeneProduct ncbigene:114118
Gna12 GeneProduct ncbigene:81663
Itpr1 GeneProduct ncbigene:25262
Slc9a1 GeneProduct ncbigene:24782
Gnai2 GeneProduct ncbigene:81664


  1. Stryer L, Bourne HR. G proteins: a family of signal transducers. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia