Type II interferon signaling (WP619)
Homo sapiens
Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP619 CPTAC Assay Portal]
Authors
Thomas Kelder , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , and Egon WillighagenActivity
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Cited By
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- LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC (2020).
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- Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification (2016).
- Prolactin Receptor in Primary Hyperparathyroidism – Expression, Functionality and Clinical Correlations (2012).
- Proteomic Consequences of a Single Gene Mutation in a Colorectal Cancer Model (2011).
- Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis (2022).
- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
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Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Pathway Ontology
Jak-Stat signaling pathway type II interferon signaling pathwayLabel | Type | Compact Identifier | Comment |
---|---|---|---|
IFNG | GeneProduct | ncbigene:3458 | |
IFNG | GeneProduct | ncbigene:3458 | |
IFNG | GeneProduct | ncbigene:3458 | |
IFNGR1 | GeneProduct | ncbigene:3459 | |
IFNGR2 | GeneProduct | ncbigene:3460 | |
JAK1 | GeneProduct | ncbigene:3716 | |
JAK2 | GeneProduct | ncbigene:3717 | |
JAK2 | GeneProduct | ncbigene:3717 | |
IFNGR2 | GeneProduct | ncbigene:3460 | |
IFNGR1 | GeneProduct | ncbigene:3459 | |
JAK1 | GeneProduct | ncbigene:3716 | |
IFNG | GeneProduct | ncbigene:3458 | |
JAK2 | GeneProduct | ncbigene:3717 | |
IFNGR2 | GeneProduct | ncbigene:3460 | |
IFNGR1 | GeneProduct | ncbigene:3459 | |
JAK1 | GeneProduct | ncbigene:3716 | |
IFNGR2 | GeneProduct | ncbigene:3460 | |
IFNG | GeneProduct | ncbigene:3458 | |
JAK1 | GeneProduct | ncbigene:3716 | |
JAK2 | GeneProduct | ncbigene:3717 | |
IFNGR1 | GeneProduct | ncbigene:3459 | |
SOCS3 | GeneProduct | ncbigene:9021 | |
SOCS1 | GeneProduct | ncbigene:8651 | |
PTPN11 | GeneProduct | ncbigene:5781 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 [P] | GeneProduct | ncbigene:6772 | |
STAT2 [P] | GeneProduct | ncbigene:6773 | |
STAT2 | GeneProduct | ncbigene:6773 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT2 | GeneProduct | ncbigene:6773 | |
STAT1 | GeneProduct | ncbigene:6772 | |
IRF9 | GeneProduct | ncbigene:10379 | |
(ISGF3) | GeneProduct | ncbigene:10379 | |
IRF9 | GeneProduct | ncbigene:10379 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
IRF9 | GeneProduct | ncbigene:10379 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
PRKCD | GeneProduct | ncbigene:5580 | |
PTP | GeneProduct | ncbigene:5967 | |
IRF4 | GeneProduct | ncbigene:3662 | |
SPI1 | GeneProduct | ncbigene:6688 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT2 | GeneProduct | ncbigene:6773 | |
STAT1 | GeneProduct | ncbigene:6772 | |
IRF9 | GeneProduct | ncbigene:10379 | |
(ISGF3) | GeneProduct | ncbigene:10379 | |
STAT1 | GeneProduct | ncbigene:6772 | |
STAT1 | GeneProduct | ncbigene:6772 | |
IRF9 | GeneProduct | ncbigene:10379 | |
IFNA | GeneProduct | ncbigene:3440 | |
IFNB1 | GeneProduct | ncbigene:3456 | |
HLA-B | GeneProduct | ncbigene:3106 | |
NOS2A | GeneProduct | ncbigene:4843 | |
GBP1 | GeneProduct | ncbigene:2633 | |
HIST2H4 | GeneProduct | ncbigene:8370 | |
PSMB9 | GeneProduct | ncbigene:5698 | |
TAP1 | GeneProduct | ncbigene:6890 | |
OAS1 | GeneProduct | ncbigene:4938 | |
CXCL10 | GeneProduct | ncbigene:3627 | |
CIITA | GeneProduct | ncbigene:4261 | |
CYBB | GeneProduct | ncbigene:1536 | |
IL1B | GeneProduct | ncbigene:3553 | |
IFIT2 | GeneProduct | ncbigene:3433 | |
EIF2AK2 | GeneProduct | ncbigene:5610 | |
G1P3 | GeneProduct | ncbigene:2537 | |
IRF1 | GeneProduct | ncbigene:3659 | |
ICAM1 | GeneProduct | ncbigene:3383 | |
CXCL9 | GeneProduct | ncbigene:4283 | |
G1P2 | GeneProduct | ncbigene:9636 | |
IRF8 [P] | GeneProduct | ncbigene:3394 | |
IRF8 | GeneProduct | ncbigene:3394 | |
IRF2 | GeneProduct | ncbigene:3660 |
References
- A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia