miR-1 in cardiac development (WP608)

Mus musculus

This pathway is an adaptation from figure 2.a in Stefani et al. (2008). miR-1 regulates cardiac morphogenesis by optimizing the level of the HAND2 transcription factor. Electric conduction is abnormal in mice that lack miR-1 as a consequence of de-inhibition of IRX5, a homeodomain-containing transcription factor that represses the expression of the KCND2 potassium channel.
last edited


Thomas Kelder , Kristina Hanspers , and Daniela Digles

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Mus musculus



Pathway Ontology: microRNA pathway


Label Type Compact Identifier Comment
Hand2 GeneProduct ncbigene:15111
Irx5 GeneProduct ncbigene:54352
Kcnd2 GeneProduct ncbigene:16508


  1. Small non-coding RNAs in animal development. Stefani G, Slack FJ. Nat Rev Mol Cell Biol. 2008 Mar;9(3):219–30. PubMed Europe PMC Scholia