EGFR1 signaling pathway (WP572)

Mus musculus

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4
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last edited

Authors

Akhilesh Pandey , Michiel Adriaens , Alex Pico , Christine Chichester , Jonathan Mlius , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Annotations

Pathway Ontology: epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact Identifier Comment
Egf GeneProduct ncbigene:13645
Raf1 GeneProduct ncbigene:110157
Hras1 GeneProduct ncbigene:15461
Nras GeneProduct ncbigene:18176
Kras GeneProduct ncbigene:16653
Shoc2 GeneProduct ncbigene:56392
PIK3R1 GeneProduct ncbigene:18708
Map3k2 GeneProduct ncbigene:26405
Grb14 GeneProduct ncbigene:50915
Grb2 GeneProduct ncbigene:14784
Grb10 GeneProduct ncbigene:14783
Map3k3 GeneProduct ncbigene:26406
Sos1 GeneProduct ncbigene:20662
Grb7 GeneProduct ncbigene:14786
Pik3r2 GeneProduct ncbigene:18709
Shc1 GeneProduct ncbigene:20416
Pik3r3 GeneProduct ncbigene:18710
Pik3ca GeneProduct ncbigene:18706
Pik3cb GeneProduct ncbigene:74769
Pik3cd GeneProduct ncbigene:18707
Pik3cg GeneProduct ncbigene:30955
Gab1 GeneProduct ncbigene:14388
Gab2 GeneProduct ncbigene:14389
Jak1 GeneProduct ncbigene:16451
Stat1 GeneProduct ncbigene:20846
Jak2 GeneProduct ncbigene:16452
Stat3 GeneProduct ncbigene:20848
Stat5a GeneProduct ncbigene:20850
Stat2 GeneProduct ncbigene:20847
Stat5b GeneProduct ncbigene:20851
Map2k1 GeneProduct ncbigene:26395
Prkca GeneProduct ncbigene:18750
MAP3K1 GeneProduct ncbigene:26401
Prkcz GeneProduct ncbigene:18762
Prkcm GeneProduct ncbigene:18760
Prkci GeneProduct ncbigene:18759
Prkcb1 GeneProduct ncbigene:18751
Map2k2 GeneProduct ncbigene:26396
Map2k3 GeneProduct ncbigene:26397
Map2k5 GeneProduct ncbigene:23938
Map3k4 GeneProduct ncbigene:26407
Vav1 GeneProduct ncbigene:22324
Vav3 GeneProduct ncbigene:57257
Vav2 GeneProduct ncbigene:22325
Mapk7 GeneProduct ncbigene:23939
Mapk1 GeneProduct ncbigene:26413
Mapk3 GeneProduct ncbigene:26417
Elk4 GeneProduct ncbigene:13714
Elk1 GeneProduct ncbigene:13712
Mapk8 GeneProduct ncbigene:26419
Map2k7 GeneProduct ncbigene:26400
Ptprr GeneProduct ncbigene:19279
Gja1 GeneProduct ncbigene:14609
Ywhab GeneProduct ncbigene:54401
Wnk1 GeneProduct ncbigene:232341
Egfr GeneProduct ncbigene:13649
Krt2-7 GeneProduct ncbigene:110310
Krt2-8 GeneProduct ncbigene:16691
Krt1-17 GeneProduct ncbigene:16667
Krt1-18 GeneProduct ncbigene:16668
LOC382523 GeneProduct ncbigene:382523
Snrpd2 GeneProduct ncbigene:107686
EPPK1 GeneProduct ncbigene:223650
Plec1 GeneProduct ncbigene:18810
Ptpn12 GeneProduct ncbigene:19248
Stat3 GeneProduct ncbigene:20848
Stat1 GeneProduct ncbigene:20846
Src GeneProduct ncbigene:20779
Cbl GeneProduct ncbigene:12402
Crk GeneProduct ncbigene:12928
Crkl GeneProduct ncbigene:12929
Ndufa13 GeneProduct ncbigene:67184
Rac1 GeneProduct ncbigene:19353
Ptk2b GeneProduct ncbigene:19229
Cav1 GeneProduct ncbigene:12389
Cav2 GeneProduct ncbigene:12390
Nck1 GeneProduct ncbigene:17973
Nck2 GeneProduct ncbigene:17974
Plcg1 GeneProduct ncbigene:18803
Git1 GeneProduct ncbigene:216963
Rgs16 GeneProduct ncbigene:19734
Socs1 GeneProduct ncbigene:12703
Socs3 GeneProduct ncbigene:12702
Inppl1 GeneProduct ncbigene:16332
Rab5a GeneProduct ncbigene:271457
Usp6nl GeneProduct ncbigene:98910
Arf4 GeneProduct ncbigene:11843
Zfp259 GeneProduct ncbigene:22687
Ripk1 GeneProduct ncbigene:19766
Map3k14 GeneProduct ncbigene:53859
Ralgds GeneProduct ncbigene:19730
Rasa1 GeneProduct ncbigene:218397
Ptk6 GeneProduct ncbigene:20459
Prkar1a GeneProduct ncbigene:19084
Ptpn6 GeneProduct ncbigene:15170
Ptpn11 GeneProduct ncbigene:19247
Plscr1 GeneProduct ncbigene:22038
Errfi1 GeneProduct ncbigene:74155
Dok2 GeneProduct ncbigene:13449
Pitpna GeneProduct ncbigene:18738
Cblc GeneProduct ncbigene:80794
Cblb GeneProduct ncbigene:208650
Pld2 GeneProduct ncbigene:18806
Pld1 GeneProduct ncbigene:18805
Prkca GeneProduct ncbigene:18750
Eps15 GeneProduct ncbigene:13858
Eps8 GeneProduct ncbigene:13860
Hdh GeneProduct ncbigene:15194
Pik3c2b GeneProduct ncbigene:240752
Sh3bgrl GeneProduct ncbigene:56726
Csk GeneProduct ncbigene:12988
Reps2 GeneProduct ncbigene:194590
Ralbp1 GeneProduct ncbigene:19765
Ralb GeneProduct ncbigene:64143
Reps1 GeneProduct ncbigene:19707
Tnk2 GeneProduct ncbigene:51789
ABI1 GeneProduct ncbigene:11308
Sos2 GeneProduct ncbigene:20663
Dnm1 GeneProduct ncbigene:13429
Sh3gl3 GeneProduct ensembl:ENSMUSG00000030638
Cdc42 GeneProduct ncbigene:12540
Spry2 GeneProduct ncbigene:24064
Jund1 GeneProduct ncbigene:16478
Fos GeneProduct ncbigene:14281
Cebpa GeneProduct ncbigene:12606
Myc GeneProduct ncbigene:17869
Cebpb GeneProduct ncbigene:12608
Pebp1 GeneProduct ncbigene:23980
Tieg3 GeneProduct ncbigene:194655
Sin3a GeneProduct ncbigene:20466
Tgif GeneProduct ncbigene:21815
Hdac1 GeneProduct ncbigene:433759
Sh3kbp1 GeneProduct ncbigene:58194
Sh3gl2 GeneProduct ncbigene:20404
Jun GeneProduct ncbigene:16476
Sp1 GeneProduct ncbigene:20683
Akt1 GeneProduct ncbigene:11651
Ptpn5 GeneProduct ncbigene:19259
Snca GeneProduct ncbigene:20617
Rps6ka1 GeneProduct ncbigene:20111
Rps6ka3 GeneProduct ncbigene:110651
Rps6ka2 GeneProduct ncbigene:20112
Ap2a1 GeneProduct ncbigene:11771
Wasl GeneProduct ncbigene:73178
Ceacam1 GeneProduct ncbigene:26365
Eef1a1 GeneProduct ncbigene:13627
2900057D21Rik GeneProduct ncbigene:72993
Dip3b GeneProduct ncbigene:216190
Mta2 GeneProduct ncbigene:23942
Eps15l1 GeneProduct ncbigene:13859
Epn1 GeneProduct ncbigene:13854
Hip1 GeneProduct ncbigene:215114
Rfxank GeneProduct ncbigene:19727
Mapk14 GeneProduct ncbigene:26416
Tnip1 GeneProduct ncbigene:57783
Egfr GeneProduct ncbigene:13649
Egfr GeneProduct ncbigene:13649
Rbbp7 GeneProduct ncbigene:245688
Ddef1 GeneProduct ncbigene:13196
Stxbp1 GeneProduct ncbigene:20910
Ctnnd1 GeneProduct ncbigene:12388
Pkn2 GeneProduct ncbigene:109333
Pak1 GeneProduct ncbigene:18479
Sh2d3c GeneProduct ncbigene:27387
Bcar1 GeneProduct ncbigene:12927
Casp9 GeneProduct ncbigene:12371
Rps6ka5 GeneProduct ncbigene:73086
Smad2 GeneProduct ncbigene:17126
Smad3 GeneProduct ncbigene:17127
Smad2 GeneProduct ncbigene:17126
Smad3 GeneProduct ncbigene:17127
ATF1 GeneProduct ncbigene:11908
Creb1 GeneProduct ncbigene:12912
Foxo1 GeneProduct ncbigene:56458
Pxn GeneProduct ncbigene:19303
Elf3 GeneProduct ncbigene:13710
Hat1 GeneProduct ncbigene:107435
Camk2a GeneProduct ncbigene:12322
Itch GeneProduct ncbigene:16396
Araf GeneProduct ncbigene:11836
Mcf2 GeneProduct ncbigene:109904
Elf3 GeneProduct ncbigene:13710
Rps6ka3 GeneProduct ncbigene:110651
Map3k2 GeneProduct ncbigene:26405
Foxo1 GeneProduct ncbigene:56458
Eps15 GeneProduct ncbigene:13858
Eef1a1 GeneProduct ncbigene:13627
Stat1 GeneProduct ncbigene:20846
Stat3 GeneProduct ncbigene:20848
Stat2 GeneProduct ncbigene:20847
Stat5a GeneProduct ncbigene:20850
Zfp259 GeneProduct ncbigene:22687
Plcg1 GeneProduct ncbigene:18803
Spry2 GeneProduct ncbigene:24064
Plcg2 GeneProduct ncbigene:234779
Plcg2 GeneProduct ncbigene:234779
Ptpn6 GeneProduct ncbigene:15170
Raf1 GeneProduct ncbigene:110157
Gab1 GeneProduct ncbigene:14388
Shc1 GeneProduct ncbigene:20416
Pld1 GeneProduct ncbigene:18805
Bcar1 GeneProduct ncbigene:12927
Sh2d3c GeneProduct ncbigene:27387
Stxbp1 GeneProduct ncbigene:20910
2900057D21Rik GeneProduct ncbigene:72993
2900057D21Rik GeneProduct ncbigene:72993
Dip3b GeneProduct ncbigene:216190
Mapk1 GeneProduct ncbigene:26413
Map2k1 GeneProduct ncbigene:26395
Dusp1 GeneProduct ncbigene:19252
Dusp1 GeneProduct ncbigene:19252
Arf4 GeneProduct ncbigene:11843
Arf4 GeneProduct ncbigene:11843
Egf GeneProduct ncbigene:13645
Egf GeneProduct ncbigene:13645
Sh3gl2 GeneProduct ncbigene:20404
Egfr GeneProduct ncbigene:13649
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References

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Control of MAPK signalling: from complexity to what really matters. Oncogene. 2005 Aug 25;24(36):5533–42. PubMed Europe PMC Scholia