DNA replication (WP565)

Drosophila melanogaster

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [[wikipedia:DNA_replication|Wikipedia]]
last edited


Kdahlquist , David Koren , Thomas Kelder , Egon Willighagen , Christine Chichester , and Eric Weitz

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Drosophila melanogaster



Pathway Ontology: DNA replication pathway


Label Type Compact Identifier Comment
CG9273 GeneProduct ncbigene:35364
DNApol-alpha180 GeneProduct ncbigene:42553
DNApol-alpha50 GeneProduct ncbigene:38942
DNAprim GeneProduct ncbigene:44915
Pole2 GeneProduct ncbigene:38661
DNApol-epsilon GeneProduct ncbigene:42758
lat GeneProduct ncbigene:36454
Orc2 GeneProduct ncbigene:41703
Orc5 GeneProduct ncbigene:34794
Orc4 GeneProduct ncbigene:37970
Orc1 GeneProduct ncbigene:35686
Orc6 GeneProduct ncbigene:36017
dup GeneProduct ncbigene:47121
RpL40 GeneProduct ncbigene:33629
Mcm6 GeneProduct ncbigene:31603
Mcm5 GeneProduct ncbigene:41296
dpa GeneProduct ncbigene:35679
Mcm3 GeneProduct ncbigene:31449
Mcm2 GeneProduct ncbigene:40973
Mcm7 GeneProduct ncbigene:39014
Mcm10 GeneProduct ncbigene:35390
DNApol-alpha73 GeneProduct ncbigene:43278
RfC3 GeneProduct ncbigene:34423
CG8142 GeneProduct ncbigene:32763
RfC38 GeneProduct ncbigene:34550
RfC40 GeneProduct ncbigene:38492
Gnf1 GeneProduct ncbigene:40607
mus209 GeneProduct ncbigene:37290
l(1)G0148 GeneProduct ncbigene:31598
RpA-70 GeneProduct ncbigene:40972
CDC45L GeneProduct ncbigene:31052
CG12018 GeneProduct ncbigene:38228
DNApol-delta GeneProduct ncbigene:39746
CG5971 GeneProduct ncbigene:38989
Ubi-p63E GeneProduct ncbigene:38456


  1. Regulation of chromosome replication. Kelly TJ, Brown GW. Annu Rev Biochem. 2000;69:829–80. PubMed Europe PMC Scholia
  2. DNA replication in eukaryotic cells. Bell SP, Dutta A. Annu Rev Biochem. 2002;71:333–74. PubMed Europe PMC Scholia