The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: [http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway WikiPedia]). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP560 CPTAC Assay Portal]

Authors

Nurit Gal , Thomas Kelder , Alex Pico , Martijn Van Iersel , Samuel Sklar , Kristina Hanspers , Irene Hemel , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology: transforming growth factor-beta superfamily mediated signaling pathway

Participants

References

1. Massagué J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell. 2000 Oct 13;103(2):295–309. PubMed Europe PMC Scholia
2. Massagué J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol. 2000 Dec;1(3):169–78. PubMed Europe PMC Scholia
3. Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010 Jul 2;7(1):36–41. PubMed Europe PMC Scholia