Biogenic amine synthesis (WP550)

Homo sapiens

Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Source: Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]
last edited


Alex Pico , Kristina Hanspers , Thomas Kelder , Martijn Van Iersel , Christine Chichester , Egon Willighagen , Chris Evelo , AAR&Co , Martina Summer-Kutmon , Eric Weitz , and Finterly Hu

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Homo sapiens



Pathway Ontology: biogenic amine biosynthetic pathway amine neurotransmitter metabolic pathway


Label Type Compact Identifier Comment
Choline Metabolite cas:62-49-7
Epinephrine Metabolite hmdb:HMDB0000068
5-hydroxy-tryptophan Metabolite cas:4350-09-8
Acetylserotonin Metabolite cas:1210-83-9
GABA Metabolite hmdb:HMDB0000112
L-DOPA Metabolite cas:59-92-7
Histidine Metabolite cas:71-00-1
Dopamine Metabolite cas:62-31-7
Acetylcholine Metabolite cas:51-84-3
Tyrosine Metabolite cas:60-18-4
Serotonin Metabolite cas:50-67-9
Phenylalanine Metabolite cas:63-91-2
Melatonin Metabolite hmdb:HMDB0001389
Glutamate Metabolite cas:56-86-0
Tryptophan Metabolite cas:73-22-3
Norepinephrine Metabolite cas:51-41-2
Histamine Metabolite cas:51-45-6
GAD2 GeneProduct ncbigene:2572
DDC GeneProduct ncbigene:1644
TPH1 GeneProduct ncbigene:7166
HDC GeneProduct ncbigene:3067
DBH GeneProduct ncbigene:1621
DDC GeneProduct ncbigene:1644
TH GeneProduct ncbigene:7054
PNMT GeneProduct ncbigene:5409
ACHE GeneProduct ncbigene:43
COMT GeneProduct ncbigene:1312
PAH GeneProduct ncbigene:5053
CHAT GeneProduct ncbigene:1103
AANAT GeneProduct ncbigene:15
GAD1 GeneProduct ncbigene:2571
MAOA GeneProduct ncbigene:4128
ASMT GeneProduct ncbigene:438
MAOA GeneProduct ncbigene:4128
DDC GeneProduct ncbigene:1644


  1. Purves D. Neuroscience [Internet]. Sinauer Associates Incorporated; 2001. 709 p. Available from: OpenLibrary Worldcat