Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP536 CPTAC Assay Portal]

Authors

Nathan Salomonis , Susan Coort , Thomas Kelder , Joanna Fong , Nathalie Cotte , AMC Human Genetics , Jildau Bouwman , Kristina Hanspers , Alex Pico , Martijn Van Iersel , Christine Chichester , Tyler Peryea , Denise Slenter , Marvin Martens , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Annotations

Cell Type Ontology: cardiac muscle cell

Pathway Ontology: calcium/calcium-mediated signaling pathway

Disease Ontology: cardiovascular system disease

Participants

References

1. Calcium and the heart: a question of life and death. Marks AR. J Clin Invest. 2003 Mar;111(5):597–600. PubMed Europe PMC Scholia