Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [http://www.wikipedia.org Wikipedia]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP534 CPTAC Assay Portal]

Authors

Kdahlquist , Susan Coort , Nick Fidelman , Martijn Van Iersel , Kristina Hanspers , Thomas Kelder , Jildau Bouwman , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , The Herald , Mirk Baranzini , Denise Slenter , Mark A. Hershberger , Ambar21 , and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology: citric acid cycle pathway gluconeogenesis pathway glycolysis/gluconeogenesis pathway

Participants

References

1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen Y-C, et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia