G13 signaling pathway (WP520)
Rattus norvegicus
The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]
Authors
Anita Chow , Manny Ramirez , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric WeitzCited In
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Organism
Rattus norvegicusCommunities
Annotations
Pathway Ontology: G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway
Participants
| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Rtkn | GeneProduct | ensembl:ENSRNOG00000059679 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6242 |
| Pkn1 | GeneProduct | ensembl:ENSRNOG00000004131 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5585 |
| Cfl2 | GeneProduct | ensembl:ENSRNOG00000045892 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1073 |
| Rhpn2 | GeneProduct | ensembl:ENSRNOG00000011885 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:85415 |
| Rhoa | GeneProduct | ensembl:ENSRNOG00000050519 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:387 |
| Mk1 | GeneProduct | ensembl:ENSRNOG00000019657 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5216 |
| Arhgef1 | GeneProduct | ensembl:ENSRNOG00000020130 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9138 |
| Cyfip1 | GeneProduct | ensembl:ENSRNOG00000011945 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23191 |
| Gna13 | GeneProduct | ensembl:ENSRNOG00000036745 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10672 |
| Iqgap2 | GeneProduct | ensembl:ENSRNOG00000025406 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10788 |
| Iqgap1 | GeneProduct | ensembl:ENSRNOG00000012002 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8826 |
| Pik3cd | GeneProduct | ensembl:ENSRNOG00000016846 | P42338Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5293 |
| Arhgdib | GeneProduct | ensembl:ENSRNOG00000005809 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:397 |
| LOC100910021 | GeneProduct | ensembl:ENSRNOG00000023622 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5291 |
| Sh3rf1 | GeneProduct | ensembl:ENSRNOG00000010358 | PoshHomology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57630 |
| Limk1 | GeneProduct | ensembl:ENSRNOG00000001470 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3984 |
| Mybph | GeneProduct | ensembl:ENSRNOG00000003336 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4608 |
| Rac1 | GeneProduct | ensembl:ENSRNOG00000001068 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5879 |
| Tnk2 | GeneProduct | ensembl:ENSRNOG00000001769 | S33596Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10188 |
| Pak3 | GeneProduct | ensembl:ENSRNOG00000004676 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5063 |
| Pip4k2a | GeneProduct | ensembl:ENSRNOG00000016670 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5305 |
| Mapk10 | GeneProduct | ensembl:ENSRNOG00000002079 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5602 |
| AABR07013776.1 | GeneProduct | ensembl:ENSRNOG00000048082 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:801 |
| Wasl | GeneProduct | ensembl:ENSRNOG00000006975 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8976 |
| Pik3r2 | GeneProduct | ensembl:ENSRNOG00000019228 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5296 |
| Ppp1cb | GeneProduct | ensembl:ENSRNOG00000004612 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5500 |
| Was | GeneProduct | ensembl:ENSRNOG00000031058 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7454 |
| Map3k4 | GeneProduct | ensembl:ENSRNOG00000017419 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4216 |
| Myl1 | GeneProduct | ensembl:ENSRNOG00000013262 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4632 |
| Cit | GeneProduct | ensembl:ENSRNOG00000001143 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11113 |
| Rock1 | GeneProduct | ensembl:ENSRNOG00000031092 | S69211Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6093 |
| Diaph1 | GeneProduct | ensembl:ENSRNOG00000019688 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1729 |
| AABR07037536.1 | GeneProduct | ensembl:ENSRNOG00000056810 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5290 |
| Cdc42 | GeneProduct | ensembl:ENSRNOG00000013536 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998 |
| Rps6kb1 | GeneProduct | ensembl:ENSRNOG00000003919 | A41687Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6198 |
| Rock2 | GeneProduct | ensembl:ENSRNOG00000004496 | BAA31594Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9475 |
References
- Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia