Taken from existing [[Pathway:WP474|Endochondral Ossification pathway]]. Added diseases linked with a dotted arrow to GeneProduct nodes, dotted arrow indicates what diseases are caused by mutation in the respective genes.

Authors

Ritchie Lee and Eric Weitz

Cited In

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Organism

Homo sapiens

Communities

Skeletal Dysplasia

Annotations

Cell Type Ontology: osteoclast obsolete osteochondroclast chondrocyte

Pathway Ontology: regulatory pathway

Participants

References

1. Mackie EJ, Ahmed YA, Tatarczuch L, Chen K-S, Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol. 2008;40(1):46–62. PubMed Europe PMC Scholia
2. Belluoccio D, Bernardo BC, Rowley L, Bateman JF. A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage. Biochim Biophys Acta. 2008 May;1779(5):330–40. PubMed Europe PMC Scholia
3. Randau TM, Schildberg FA, Alini M, Wimmer MD, Haddouti E-M, Gravius S, et al. The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells. PLoS One. 2013 Aug 16;8(8):e72973. PubMed Europe PMC Scholia