Hippo signaling regulation pathways (WP4540)
Homo sapiens
Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT). This pathway was created based on figure 2 from Sekido et al. Phosphorylation sites were added based on information from PhosphoSitePlus, www.phosphosite.org.
Authors
Alex Pico , Eric Weitz , Friederike Ehrhart , and Kristina HanspersActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
- Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain (2022).
- β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells (2021).
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
Diseases Rare DiseasesAnnotations
Pathway Ontology
disease pathway Hippo signaling pathway signaling pathwayDisease Ontology
malignant mesothelioma| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PRKAA1 | GeneProduct | ncbigene:5562 | AMPK |
| PRKAA2 | GeneProduct | ncbigene:5563 | AMPK |
| PRKAB1 | GeneProduct | ncbigene:5564 | AMPK |
| PRKAB2 | GeneProduct | ncbigene:5565 | AMPK |
| PRKAG1 | GeneProduct | ncbigene:5571 | AMPK |
| PRKAG2 | GeneProduct | ncbigene:51422 | AMPK |
| PRKAG3 | GeneProduct | ncbigene:53632 | AMPK |
| CDH1 | GeneProduct | ncbigene:999 | Cadherin |
| CDH10 | GeneProduct | ncbigene:1008 | Cadherin |
| CDH11 | GeneProduct | ncbigene:1009 | Cadherin |
| CDH12 | GeneProduct | ncbigene:1010 | Cadherin |
| CDH13 | GeneProduct | ncbigene:1012 | Cadherin |
| CDH15 | GeneProduct | ncbigene:1013 | Cadherin |
| CDH16 | GeneProduct | ncbigene:1014 | Cadherin |
| CDH17 | GeneProduct | ncbigene:1015 | Cadherin |
| CDH18 | GeneProduct | ncbigene:1016 | Cadherin |
| CDH19 | GeneProduct | ncbigene:28513 | Cadherin |
| CDH2 | GeneProduct | ncbigene:1000 | Cadherin |
| CDH20 | GeneProduct | ncbigene:28316 | Cadherin |
| CDH22 | GeneProduct | ncbigene:64405 | Cadherin |
| CDH24 | GeneProduct | ncbigene:64403 | Cadherin |
| CDH3 | GeneProduct | ncbigene:1001 | Cadherin |
| CDH4 | GeneProduct | ncbigene:1002 | Cadherin |
| CDH5 | GeneProduct | ncbigene:1003 | Cadherin |
| CDH6 | GeneProduct | ncbigene:1004 | Cadherin |
| CDH7 | GeneProduct | ncbigene:1005 | Cadherin |
| CDH8 | GeneProduct | ncbigene:1006 | Cadherin |
| CDH9 | GeneProduct | ncbigene:1007 | Cadherin |
| GNA11 | GeneProduct | ncbigene:2767 | Ga/1 |
| GNAI2 | GeneProduct | ncbigene:2771 | Ga/1 |
| GNAI3 | GeneProduct | ncbigene:2773 | Ga/1 |
| GNAL | GeneProduct | ncbigene:2774 | Ga/1 |
| GNAQ | GeneProduct | ncbigene:2776 | Ga/1 |
| GNAS | GeneProduct | ncbigene:2778 | Ga/1 |
| PRKACA | GeneProduct | ncbigene:5566 | PKA |
| PRKACB | GeneProduct | ncbigene:5567 | PKA |
| PRKACG | GeneProduct | ncbigene:5568 | PKA |
| PRKAR1A | GeneProduct | ncbigene:5573 | PKA |
| PRKAR1B | GeneProduct | ncbigene:5575 | PKA |
| PRKAR2A | GeneProduct | ncbigene:5576 | PKA |
| PRKAR2B | GeneProduct | ncbigene:5577 | PKA |
| PRKCA | GeneProduct | ncbigene:5578 | PKC |
| PRKCB | GeneProduct | ncbigene:5579 | PKC |
| PRKCD | GeneProduct | ncbigene:5580 | PKC |
| PRKCE | GeneProduct | ncbigene:5581 | PKC |
| PRKCG | GeneProduct | ncbigene:5582 | PKC |
| PRKCH | GeneProduct | ncbigene:5583 | PKC |
| PRKCI | GeneProduct | ncbigene:5584 | PKC |
| PRKCQ | GeneProduct | ncbigene:5588 | PKC |
| PRKCZ | GeneProduct | ncbigene:5590 | PKC |
| PRKD3 | GeneProduct | ncbigene:23683 | PKC |
| PLCB1 | GeneProduct | ncbigene:23236 | PLCB |
| PLCB2 | GeneProduct | ncbigene:5330 | PLCB |
| PLCB3 | GeneProduct | ncbigene:5331 | PLCB |
| PLCB4 | GeneProduct | ncbigene:5332 | PLCB |
| SMAD3 | GeneProduct | ncbigene:4088 | SMAD |
| CDC42 | GeneProduct | ncbigene:998 | |
| SMAD2 | GeneProduct | ncbigene:4087 | SMAD |
| MTOR | GeneProduct | ncbigene:2475 | mTOR |
| LATS2 | GeneProduct | ncbigene:26524 | LATS1/2 |
| STK3 | GeneProduct | ncbigene:6788 | MST1/2 |
| LATS1 | GeneProduct | ncbigene:9113 | LATS1/2 |
| NF2 | GeneProduct | ncbigene:4771 | Nf2 |
| STK4 | GeneProduct | ncbigene:4485 | MST1/2 |
| TEAD1 | GeneProduct | ensembl:ENSG00000187079 | |
| TEAD2 | GeneProduct | ensembl:ENSG00000074219 | |
| TEAD3 | GeneProduct | ensembl:ENSG00000007866 | |
| TEAD4 | GeneProduct | ensembl:ENSG00000197905 | |
| FGFR2 | GeneProduct | ensembl:ENSG00000066468 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183 |
| KDR | GeneProduct | ensembl:ENSG00000128052 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542 |
| INSR | GeneProduct | ensembl:ENSG00000171105 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337 |
| FGFR3 | GeneProduct | ensembl:ENSG00000068078 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184 |
| IGF1R | GeneProduct | ensembl:ENSG00000140443 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001 |
| KIT | GeneProduct | ensembl:ENSG00000157404 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590 |
| FGFR1 | GeneProduct | ensembl:ENSG00000077782 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182 |
| EPHA2 | GeneProduct | ensembl:ENSG00000142627 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836 |
| EGFR | GeneProduct | ensembl:ENSG00000146648 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649 |
| CSF1R | GeneProduct | ensembl:ENSG00000182578 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978 |
| FGFR4 | GeneProduct | ensembl:ENSG00000160867 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186 |
| FLT1 | GeneProduct | ensembl:ENSG00000102755 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254 |
| FLT4 | GeneProduct | ensembl:ENSG00000037280 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257 |
| NGFR | GeneProduct | ensembl:ENSG00000064300 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053 |
| MET | GeneProduct | ensembl:ENSG00000105976 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295 |
| PDGFRA | GeneProduct | ensembl:ENSG00000134853 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595 |
| PDGFRB | GeneProduct | ensembl:ENSG00000113721 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596 |
| TEK | GeneProduct | ensembl:ENSG00000120156 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 |
| FLT3 | GeneProduct | ensembl:ENSG00000122025 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257 |
| NTRK1 | GeneProduct | ensembl:ENSG00000198400 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 |
| NTRK2 | GeneProduct | ensembl:ENSG00000148053 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687 |
| RHOA | GeneProduct | ncbigene:387 | |
| RAC1 | GeneProduct | ncbigene:5879 | |
| LEF1 | GeneProduct | ensembl:ENSG00000138795 | |
| TCF7L1 | GeneProduct | ensembl:ENSG00000152284 | |
| TCF7L2 | GeneProduct | ensembl:ENSG00000148737 | |
| TCF7 | GeneProduct | ensembl:ENSG00000081059 | |
| CTNNB1 | GeneProduct | ncbigene:1499 | |
| WWTR1 | GeneProduct | ncbigene:25937 | |
| YAP1 | GeneProduct | ncbigene:10413 | |
| WWTR1 | GeneProduct | ncbigene:25937 | |
| YAP1 | GeneProduct | ncbigene:10413 |
References
- Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Sekido Y. Cancers (Basel). 2018 Mar 22;10(4):90. PubMed Europe PMC Scholia