DNA replication (WP451)

Danio rerio

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [[wikipedia:DNA_replication|Wikipedia]]
last edited


Kdahlquist , David Koren , Thomas Kelder , Christine Chichester , Levi Wackers , and Eric Weitz

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Danio rerio



Pathway Ontology: DNA replication pathway


Label Type Compact Identifier Comment
zgc:110727 GeneProduct ncbigene:407653
CDC6 GeneProduct ensembl:ENSDARG00000009942
POLE2 GeneProduct ncbigene:192320
zgc:77841 GeneProduct ncbigene:322059
rfc4 GeneProduct ncbigene:406435
rfc5 GeneProduct ncbigene:445385
rpa2 GeneProduct ncbigene:65226
UBC GeneProduct ensembl:ENSDARG00000102632
POLE GeneProduct ncbigene:553405
POLD1 GeneProduct ncbigene:556456
mcm2 GeneProduct ncbigene:192338
pcna GeneProduct ncbigene:30678
rfc3 GeneProduct ncbigene:259256
mcm5 GeneProduct ncbigene:286747
zgc:77827 GeneProduct ncbigene:406479
zgc:85772 GeneProduct ncbigene:406462
pold2 GeneProduct ensembl:ENSDARG00000095046
rpa1 GeneProduct ncbigene:327491
UBA52 GeneProduct ncbigene:641289
MCM10 GeneProduct ncbigene:553396
POLA1 GeneProduct ensembl:ENSDARG00000045308
zgc:101602 GeneProduct ncbigene:492768
prim1 GeneProduct ncbigene:30440
POLD3 GeneProduct ensembl:ENSDARG00000076169
gmnn GeneProduct ncbigene:368320
ORC2 GeneProduct ensembl:ENSDARG00000101465
RFC1 GeneProduct ensembl:ENSDARG00000054799
orc3l GeneProduct ncbigene:334315
MCM6 GeneProduct ncbigene:566409
mcm3 GeneProduct ncbigene:192323
CDT1 GeneProduct ncbigene:566787
zgc:56598 GeneProduct ncbigene:406715
zgc:56310 GeneProduct ncbigene:393196
orc6 GeneProduct ncbigene:324256
mcm4 GeneProduct ncbigene:337598
MCM7 GeneProduct ncbigene:192333
zgc:56264 GeneProduct ncbigene:406695
zgc:110810 GeneProduct ncbigene:503748
orc1 GeneProduct ensembl:ENSDARG00000039217
POLA2 GeneProduct ensembl:ENSDARG00000015070


  1. Regulation of chromosome replication. Kelly TJ, Brown GW. Annu Rev Biochem. 2000;69:829–80. PubMed Europe PMC Scholia
  2. DNA replication in eukaryotic cells. Bell SP, Dutta A. Annu Rev Biochem. 2002;71:333–74. PubMed Europe PMC Scholia