Cells and molecules involved in local acute inflammatory response (WP4493)

Homo sapiens

Cells and Molecules involved in local acute inflammatory response. Pathway based on Biocarta pathway (M3952) https://cgap.nci.nih.gov/Pathways/BioCarta/h_LairPathway Tissue damage induces the release of inflammatory signaling molecules. Additionally, bacterial infection stimulates an immune response. Bacterial infection can activate macrophages and induce the release of pro-inflammatory cytokines such as TNF, IL-6 and IL-1. Both tissue damage and bacterial infection can induce complement activation, either via the alternative or classical pathway. Leukocytes can be attracted via pro-inflammatory cytokines and chemokines released by mast cells and activated macrophages. Leukocytes can also induce complement activation. The combined response can result in a more permeable endothelium of blood vessels, induce swelling and activate immune cells.


Laurent Winckers , Eric Weitz , Susan Coort , and Egon Willighagen


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Homo sapiens



Pathway Ontology

inflammatory response pathway


Label Type Compact Identifier Comment
C3 GeneProduct ncbigene:718
C5 GeneProduct ncbigene:727
C6 GeneProduct ncbigene:729
C7 GeneProduct ncbigene:730
IL1A GeneProduct ncbigene:3552
KNG1 GeneProduct ncbigene:3827
IL6 GeneProduct ncbigene:3569
IL8 GeneProduct ncbigene:3576
TNF GeneProduct ncbigene:7124
SELPLG GeneProduct ncbigene:6404
SELP GeneProduct ncbigene:6403
ICAM1 GeneProduct ncbigene:3383
ITGAL GeneProduct ncbigene:3683
ITGB2 GeneProduct ncbigene:3689
C5 GeneProduct ncbigene:727
C3 GeneProduct ncbigene:718
VCAM1 GeneProduct ncbigene:7412
ITGB1 GeneProduct ncbigene:3688
ITGA4 GeneProduct ncbigene:3676


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  3. Mechanisms of tissue damage in arthritis. Blüml S, Redlich K, Smolen JS. Semin Immunopathol. 2014 Sep;36(5):531–40. PubMed Europe PMC Scholia