Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]

Authors

Kdahlquist , Meredith Braymer , Kristina Hanspers , Thomas Kelder , Daniela Digles , and Eric Weitz

Cited In

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Organism

Mus musculus

Communities

Annotations

Pathway Ontology: cell-extracellular matrix signaling pathway

Participants

References

1. Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia