Nonalcoholic fatty liver disease (WP4396)

Homo sapiens

Nonalcoholic fatty liver disease (NAFLD) is a condition in which too much fat is stored in the liver. Nonalcoholic steatohepatitis (NASH) is a type of NAFLD marked by liver inflammation, which may progress to scarring and irreversible damage similar to that caused by heavy alcohol use. Components of glucose matabolism, insulin signaling, inflammation, oxidative stress, ER sgtress and apoptosis are all involved and interconnected in the progression of this disease.


Alex Pico and Egon Willighagen


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Homo sapiens




Cell Type Ontology


Disease Ontology

non-alcoholic fatty liver disease

Pathway Ontology

disease pathway liver disease pathway


Label Type Compact Identifier Comment
oxysterols Metabolite chebi:53030
ROS Metabolite chebi:26523
selonsertib Metabolite wikidata:Q27088777
D-glucose Metabolite chebi:42758
fatty acids Metabolite chebi:35366
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
PIK3CA GeneProduct ncbigene:5290
PIK3CD GeneProduct ncbigene:5293
PIK3CB GeneProduct ncbigene:5291
PIK3R1 GeneProduct ncbigene:5295
PIK3R2 GeneProduct ncbigene:5296
PIK3R3 GeneProduct ncbigene:8503
AKT1 GeneProduct ncbigene:207
AKT2 GeneProduct ncbigene:208
AKT3 GeneProduct ncbigene:10000
GSK3A GeneProduct ncbigene:2931
GSK3B GeneProduct ncbigene:2932
IL1A GeneProduct ncbigene:3552
IL1B GeneProduct ncbigene:3553
MLX GeneProduct ncbigene:6945
MLXIP GeneProduct ncbigene:22877
MLXIPL GeneProduct ncbigene:51085
ADIPOR1 GeneProduct ncbigene:51094
ADIPOR2 GeneProduct ncbigene:79602
PRKAA1 GeneProduct ncbigene:5562
PRKAA2 GeneProduct ncbigene:5563
PRKAB1 GeneProduct ncbigene:5564
PRKAB2 GeneProduct ncbigene:5565
PRKAG1 GeneProduct ncbigene:5571
PRKAG3 GeneProduct ncbigene:53632
PRKAG2 GeneProduct ncbigene:51422
CDC42 GeneProduct ncbigene:998
RAC1 GeneProduct ncbigene:5879
JNK2 GeneProduct ncbigene:5601
CXCL8 GeneProduct ncbigene:3576
TGFB1 GeneProduct ncbigene:7040
CASP3 GeneProduct ncbigene:836
CASP7 GeneProduct ncbigene:840
NDUFV1 GeneProduct ncbigene:4723
NDUFV2 GeneProduct ncbigene:4729
NDUFV3 GeneProduct ncbigene:4731
NDUFA1 GeneProduct ncbigene:4694
NDUFA2 GeneProduct ncbigene:4695
NDUFA3 GeneProduct ncbigene:4696
NDUFA4 GeneProduct ncbigene:4697
NDUFA4L2 GeneProduct ncbigene:56901
NDUFA5 GeneProduct ncbigene:4698
NDUFA6 GeneProduct ncbigene:4700
NDUFA7 GeneProduct ncbigene:4701
NDUFA8 GeneProduct ncbigene:4702
NDUFA9 GeneProduct ncbigene:4704
NDUFA10 GeneProduct ncbigene:4705
NDUFAB1 GeneProduct ncbigene:4706
NDUFA11 GeneProduct ncbigene:126328
NDUFA12 GeneProduct ncbigene:55967
NDUFA13 GeneProduct ncbigene:51079
NDUFB1 GeneProduct ncbigene:4707
NDUFB2 GeneProduct ncbigene:4708
NDUFB3 GeneProduct ncbigene:4709
NDUFB4 GeneProduct ncbigene:4710
NDUFB5 GeneProduct ncbigene:4711
NDUFB6 GeneProduct ncbigene:4712
NDUFB7 GeneProduct ncbigene:4713
NDUFB8 GeneProduct ncbigene:4714
NDUFB9 GeneProduct ncbigene:4715
NDUFB10 GeneProduct ncbigene:4716
NDUFB11 GeneProduct ncbigene:54539
NDUFS1 GeneProduct ncbigene:4719
NDUFS2 GeneProduct ncbigene:4720
NDUFS3 GeneProduct ncbigene:4722
NDUFS4 GeneProduct ncbigene:4724
NDUFS5 GeneProduct ncbigene:4725
NDUFS6 GeneProduct ncbigene:4726
NDUFS7 GeneProduct ncbigene:374291
NDUFS8 GeneProduct ncbigene:4728
NDUFC1 GeneProduct ncbigene:4717
NDUFC2 GeneProduct ncbigene:4718
NDUFC2-KCTD14 GeneProduct ncbigene:100532726
SDHA GeneProduct ncbigene:6389
SDHB GeneProduct ncbigene:6390
SDHC GeneProduct ncbigene:6391
SDHD GeneProduct ncbigene:6392
UQCRFS1 GeneProduct ncbigene:7386
CYTB GeneProduct ncbigene:4519
CYC1 GeneProduct ncbigene:1537
UQCRC1 GeneProduct ncbigene:7384
UQCRC2 GeneProduct ncbigene:7385
UQCRH GeneProduct ncbigene:7388
UQCRHL GeneProduct ncbigene:440567
UQCRB GeneProduct ncbigene:7381
UQCRQ GeneProduct ncbigene:27089
UQCR10 GeneProduct ncbigene:29796
UQCR11 GeneProduct ncbigene:10975
COX3 GeneProduct ncbigene:4514
COX1 GeneProduct ncbigene:4512
COX2 GeneProduct ncbigene:4513
COX4I2 GeneProduct ncbigene:84701
COX4I1 GeneProduct ncbigene:1327
COX5A GeneProduct ncbigene:9377
COX5B GeneProduct ncbigene:1329
COX6A1 GeneProduct ncbigene:1337
COX6A2 GeneProduct ncbigene:1339
COX6B1 GeneProduct ncbigene:1340
COX6B2 GeneProduct ncbigene:125965
COX6C GeneProduct ncbigene:1345
COX7A1 GeneProduct ncbigene:1346
COX7A2 GeneProduct ncbigene:1347
COX7A2L GeneProduct ncbigene:9167
COX7B GeneProduct ncbigene:1349
COX7B2 GeneProduct ncbigene:170712
COX7C GeneProduct ncbigene:1350
COX8C GeneProduct ncbigene:341947
COX8A GeneProduct ncbigene:1351
TRAF2 GeneProduct ncbigene:7186
SREBF1 GeneProduct ncbigene:6720
IRS1 GeneProduct ncbigene:3667
CYCS GeneProduct ncbigene:54205
TNF GeneProduct ncbigene:7124
FXR GeneProduct ncbigene:9971
EIF2AK3 GeneProduct ncbigene:9451
BAK1 GeneProduct ncbigene:578
XBP1 GeneProduct ncbigene:7494
ATF4 GeneProduct ncbigene:468
CEBPA GeneProduct ncbigene:1050
NR1H3 GeneProduct ncbigene:10062
PKLR GeneProduct ncbigene:5313
INS GeneProduct ncbigene:3630
BAX GeneProduct ncbigene:581
DDIT3 GeneProduct ncbigene:1649
IL6R GeneProduct ncbigene:3570
FASLG GeneProduct ncbigene:356
LEPR GeneProduct ncbigene:3953
LEP GeneProduct ncbigene:3952
MAP3K5 GeneProduct ncbigene:4217
CASP8 GeneProduct ncbigene:841
EIF2S1 GeneProduct ncbigene:1965
ERN1 GeneProduct ncbigene:2081
INSR GeneProduct ncbigene:3643
BID GeneProduct ncbigene:637
IKBKB GeneProduct ncbigene:3551
FAS GeneProduct ncbigene:355
PPARA GeneProduct ncbigene:5465
RXRA GeneProduct ncbigene:6256
MAP3K11 GeneProduct ncbigene:4296
BBC3 GeneProduct ncbigene:27113
JNK1 GeneProduct ncbigene:5599
TNFR1 GeneProduct ncbigene:7132
IRS2 GeneProduct ncbigene:8660
CYP2E1 GeneProduct ncbigene:1571
JUN GeneProduct ncbigene:3725
ITCH GeneProduct ncbigene:83737
SOCS3 GeneProduct ncbigene:9021
ADIPOQ GeneProduct ncbigene:9370
IL6 GeneProduct ncbigene:3569
IL6 GeneProduct ncbigene:3569
IL1A GeneProduct ncbigene:3552
TNF GeneProduct ncbigene:7124
TNF GeneProduct ncbigene:7124
FASLG GeneProduct ncbigene:356
IL1B GeneProduct ncbigene:3553
BIM GeneProduct ncbigene:10018
CCL2 GeneProduct ncbigene:6347
VCAM1 GeneProduct ncbigene:7412
SMAD7 GeneProduct ncbigene:4092


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