Oxidation by cytochrome P450 (WP43)

Homo sapiens

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP43 CPTAC Assay Portal]
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Authors

Arik , Martijn Van Iersel , Thomas Kelder , Chris Evelo , Susan Coort , Mohhafez , Christine Chichester , Egon Willighagen , Kristina Hanspers , Zahra Roudbari , Martina Summer-Kutmon , Zhangx888 , Eric Weitz , and Finterly Hu

Cited In

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Organism

Homo sapiens

Communities

Annotations

Pathway Ontology: phase I biotransformation pathway via cytochrome P450 xenobiotics biodegradation pathway

Cell Type Ontology: hepatocyte

Participants

Label Type Compact Identifier Comment
NADPH Metabolite chebi:16474
O2 Metabolite hmdb:HMDB0001377
O2 Metabolite hmdb:HMDB0001377
Fe3+ Metabolite chebi:29034
H2O Metabolite hmdb:HMDB0002111
activated O2 Metabolite hmdb:HMDB0001377
Substrate Metabolite wikidata:Q12119506
Substrate-OH Metabolite wikidata:Q542929
NADP+ Metabolite chebi:18009
Fe3+ Metabolite chebi:29034
Fe3+ Metabolite chebi:29034
Fe2+ Metabolite chebi:29033
Fe2+ Metabolite chebi:29033
Substrate Metabolite wikidata:Q12119506
Substrate Metabolite wikidata:Q12119506
Fe2+ Metabolite chebi:29033
Substrate Metabolite wikidata:Q12119506
Fe3+ Metabolite chebi:29034
Substrate Metabolite wikidata:Q12119506
Fe2+ Metabolite chebi:29033
NADH Metabolite chebi:16908
NAD+ Metabolite chebi:15846
CYP26A1 GeneProduct ensembl:ENSG00000095596
CYP4F11 GeneProduct ensembl:ENSG00000171903
CYB5B GeneProduct ensembl:ENSG00000103018
CYP GeneProduct ncbigene:1559
CYP2C8 GeneProduct ensembl:ENSG00000138115
CYP2B6 GeneProduct ensembl:ENSG00000197408
CYB5R1 GeneProduct ensembl:ENSG00000159348
CYP4F22 GeneProduct ensembl:ENSG00000171954
CYB5A GeneProduct ensembl:ENSG00000166347
CYP GeneProduct ncbigene:1559
CYP4Z1 GeneProduct ensembl:ENSG00000186160
CYP GeneProduct ncbigene:1559
CYP4F8 GeneProduct ensembl:ENSG00000186526
CYP1B1 GeneProduct ensembl:ENSG00000138061
CYP2C18 GeneProduct ensembl:ENSG00000108242
CYB5R4 GeneProduct ensembl:ENSG00000065615
CYP4A22 GeneProduct ensembl:ENSG00000162365
CYB5B GeneProduct ensembl:ENSG00000103018
CYB5R2 GeneProduct ensembl:ENSG00000166394
CYP11B1 GeneProduct ensembl:ENSG00000160882
CYP27B1 GeneProduct ensembl:ENSG00000111012
CYP2A6 GeneProduct ensembl:ENSG00000255974
CYP4F3 GeneProduct ensembl:ENSG00000186529
CYP26C1 GeneProduct ensembl:ENSG00000187553
CYP GeneProduct ncbigene:1559
CYP51A1 GeneProduct ensembl:ENSG00000001630
CYP4A11 GeneProduct ensembl:ENSG00000187048
CYP2A7 GeneProduct ensembl:ENSG00000198077
CYB5B GeneProduct ensembl:ENSG00000103018
CYP7B1 GeneProduct ensembl:ENSG00000172817
CYP GeneProduct ncbigene:1559
CYP19A1 GeneProduct ensembl:ENSG00000137869
CYP21A2 GeneProduct ensembl:ENSG00000198457
CYP3A43 GeneProduct ensembl:ENSG00000021461
CYP26B1 GeneProduct ensembl:ENSG00000003137
CYP7A1 GeneProduct ensembl:ENSG00000167910
CYP3A4 GeneProduct ensembl:ENSG00000160868
CYP2W1 GeneProduct ensembl:ENSG00000073067
CYP8B1 GeneProduct ensembl:ENSG00000180432
CYP2S1 GeneProduct ensembl:ENSG00000167600
CYP39A1 GeneProduct ensembl:ENSG00000146233
CYP2R1 GeneProduct ensembl:ENSG00000186104
CYP46A1 GeneProduct ensembl:ENSG00000036530
CYP4B1 GeneProduct ensembl:ENSG00000142973
CYP1A2 GeneProduct ensembl:ENSG00000140505
CYP4V2 GeneProduct ensembl:ENSG00000145476
CYP2U1 GeneProduct ensembl:ENSG00000155016
CYP2J2 GeneProduct ensembl:ENSG00000134716
CYP2G1P GeneProduct ensembl:ENSG00000130612
CYP4X1 GeneProduct ensembl:ENSG00000186377
CYP51A1 GeneProduct ensembl:ENSG00000001630
CYP2E1 GeneProduct ensembl:ENSG00000130649
CYP11A1 GeneProduct ensembl:ENSG00000140459
CYP20A1 GeneProduct ensembl:ENSG00000119004
POR GeneProduct ensembl:ENSG00000127948
CYP17A1 GeneProduct ensembl:ENSG00000148795
CYP4F2 GeneProduct ensembl:ENSG00000186115
CYP3A5 GeneProduct ensembl:ENSG00000106258
CYP27A1 GeneProduct ensembl:ENSG00000135929
CYP2A13 GeneProduct ensembl:ENSG00000197838
CYP2F1 GeneProduct ensembl:ENSG00000197446
CYP2C19 GeneProduct ensembl:ENSG00000165841
CYP27C1 GeneProduct ensembl:ENSG00000186684
CYB5R3 GeneProduct ensembl:ENSG00000100243
CYP11B2 GeneProduct ensembl:ENSG00000179142
CYP24A1 GeneProduct ensembl:ENSG00000019186
CYP2C9 GeneProduct ensembl:ENSG00000138109
CYP4F12 GeneProduct ensembl:ENSG00000186204
CYP1A1 GeneProduct ensembl:ENSG00000140465
CYB5A GeneProduct ensembl:ENSG00000166347
CYB5A GeneProduct ensembl:ENSG00000166347
CYP2D6 GeneProduct ensembl:ENSG00000100197
CYP3A7 GeneProduct ensembl:ENSG00000160870
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References

  1. Hollinger MA, Niesink R, De Vries J. Toxicology [Internet]. Boca Raton, FL: CRC Press; 1996. 1284 p. Available from: https://openlibrary.org/books/OL791209M/Toxicology OpenLibrary Worldcat