Ketone bodies synthesis and degradation (WP427)

Caenorhabditis elegans

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]
last edited


Niradiz Reyes , Thomas Kelder , Daniela Digles , Egon Willighagen , Kristina Hanspers , and Eric Weitz

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Caenorhabditis elegans



Pathway Ontology: ketone bodies metabolic pathway


Label Type Compact Identifier Comment
3-Hydroxy-butyrate Metabolite chebi:37054
Acetoacetate Metabolite chebi:13705
3-Hydroxy-3-methylglutaryl-CoA Metabolite chebi:11814
Acetyl-CoA Metabolite chebi:15351
Acetyl-CoA Metabolite chebi:15351
Acetoacetyl-CoA Metabolite chebi:15345
kat-1 GeneProduct ncbigene:174161
HMGCS2 GeneProduct ncbigene:
Y71G12B.10 GeneProduct ncbigene:171738
C05C10.3 GeneProduct ncbigene:174548
BDH GeneProduct ncbigene:


  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia